Gestational Age at Birth and Mortality in Young Adulthood EDITORIAL COMMENT

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Winkleby Marilyn A.) > Gestational Age at ...

Gestational Age at Birth and Mortality in Young Adulthood EDITORIAL COMMENT

Crump, Casey (author)

Sundquist, Kristina (author): Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups

Sundquist, Jan (author): Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups

Winkleby, Marilyn A. (author)

show less...

(creator_code:org_t)

2012
2012
English.
In: Obstetrical and Gynecological Survey. - 0029-7828. ; 67:1, s. 12-13

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (other academic/artistic)

Abstract Subject headings

Preterm birth is associated with increased rates of neonatal and infant mortality. It has been hypothesized that gestational age at birth may also be associated with increased mortality rates in adulthood, but to date, no studies have demonstrated this relationship. This national cohort study investigated the association between gestational age at birth and mortality in young adulthood. Data obtained from the Swedish Birth Registry identified 678,528 individuals who were born as singletons between 1973 and 1979 and survived to age 1 year. Among this cohort, 674,820 were included in the final analysis. Of these, 27,979 (4.1%) born preterm (<37 weeks) were followed to age 29 to 36 years (up to 2008). The primary study outcome measures were all-cause and cause-specific mortality. Cox proportional hazards regression was used to estimate the association between gestational age at birth and mortality for 4 age categories: early childhood (age, 1-5 years), late childhood (age, 6-12 years), adolescence (age, 13-17 years), and young adulthood (age, 18-36 years). There were 7095 deaths reported in 20.8 million person-years of follow-up. A strong inverse association was found between gestational age at birth for 2 of the age categories and mortality among individuals still alive at the beginning of each age range. The adjusted hazard ratio [aHR] for each additional week of gestation in early childhood was 0.92 (95% confidence interval [CI], 0.89-0.94; P < 0.001). This inverse association disappeared in late childhood (aHR, 0.99; 95% CI, 0.95-1.03; P = 0.61) and adolescence (aHR, 0.99; 95% CI, 0.95-1.03; P = 0.64), and reappeared in young adulthood (aHR, 0.96; 95% CI, 0.94-0.97; P < 0.001). In young adulthood, the gestational age at birth was associated with mortality rates (per 1000 person-years) as follows: the aHR was 0.94 for 22 to 27 weeks, 0.86 for 28 to 33 weeks, 0.65 for 34 to 36 weeks, 0.46 for 37 to 42 weeks (full-term), and 0.54 for 43 or more weeks (P < 0.001 for all). Relative to individuals born full-term, preterm birth was associated with increased mortality in young adulthood even among individuals born late preterm (34-36 weeks); the aHR was 1.31, with a 95% CI of 1.13-1.50; P < 0.001). Moreover, gestational age at birth in young adulthood had the strongest inverse association with mortality from congenital anomalies, as well as respiratory, endocrine, and cardiovascular disorders, and it had no association with mortality from neurological disorders, cancer, or injury.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Publication and Content Type

art (subject category)
vet (subject category)

Find in a library

Obstetrical and Gynecological Survey (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Crump, Casey; Sundquist, Krist ...; Sundquist, Jan; Winkleby, Marily ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Obstetrical and ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se