WFRF:(Yan Hongji)
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Portable Quartz Crystal Resonator Sensor for Characterising the Gelation Kinetics and Viscoelastic Properties of Hydrogels
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- Miranda-Martinez, Andres (författare)
- Univ Politecn Madrid UPM, Ctr Biomed Technol CTB, Madrid 28040, Spain.
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- Yan, Hongji (författare)
- Karolinska Institutet,KTH,Glykovetenskap,Center for the Advancement of Integrated Medical and Engineering Sciences, AIMES,Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
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- Silveira, Valentin (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Skogens biomaterial och teknologi,Department of Forest Biomaterials and Technology
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- Univ Politecn Madrid UPM, Ctr Biomed Technol CTB, Madrid 28040, Spain Glykovetenskap (creator_code:org_t)
- 2022-11-07
- 2022
- Engelska.
- Ingår i: Gels. - : MDPI AG. - 2310-2861. ; 8:11, s. 718-
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Hydrogel biomaterials have found use in various biomedical applications partly due to their biocompatibility and tuneable viscoelastic properties. The ideal rheological properties of hydrogels depend highly on the application and should be considered early in the design process. Rheometry is the most common method to study the viscoelastic properties of hydrogels. However, rheometers occupy much space and are costly instruments. On the other hand, quartz crystal resonators (QCRs) are devices that can be used as low-cost, small, and accurate sensors to measure the viscoelastic properties of fluids. For this reason, we explore the capabilities of a low-cost and compact QCR sensor to sense and characterise the gelation process of hydrogels while using a low sample amount and by sensing two different crosslink reactions: covalent bonds and divalent ions. The gelation of covalently crosslinked mucin hydrogels and physically crosslinked alginate hydrogels could be monitored using the sensor, clearly distinguishing the effect of several parameters affecting the viscoelastic properties of hydrogels, including crosslinking chemistry, polymer concentrations, and crosslinker concentrations. QCR sensors offer an economical and portable alternative method to characterise changes in a hydrogel material's viscous properties to contribute to this type of material design, thus providing a novel approach.
Ämnesord
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
Nyckelord
- covalently crosslinked hydrogels
- hydrogel kinetics characterisation
- physically crosslinked hydrogels
- quartz crystal resonator
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