L773:0887 4476 OR L773:1098 2396
Sökning: L773:0887 4476 OR L773:1098 2396 > Low mRNA levels of ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02265naa a2200373 4500 | |
| 001 | oai:DiVA.org:uu-93408 | |
| 003 | SwePub | |
| 008 | 050908s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-934082 URI |
| 024 | 7 | a https://doi.org/10.1002/SYN.202262 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Emilsson, Linau Uppsala universitet,Zoologisk utvecklingsbiologi,beteende genetik4 aut |
| 245 | 1 0 | a Low mRNA levels of RGS4 splice variants in Alzheimer’s disease and association between a rare haplotype and decreased mRNA expression |
| 264 | 1 | c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a Regulator of G-protein signaling 4 (RGS4) showed decreased mRNAlevels in Alzheimer’s disease in a large collection of human brain autopsies from prefrontalcortex. The expression levels of three RGS4 splice variants were examined inthe same samples, and the association between RGS4 gene expression and/or the diseasewith single nucleotide polymorphisms located in this gene was explored. We showthat all splice variants are down-regulated in patients. We also demonstrate that onerare haplotype (ATAG) is associated with decreased mRNA levels in both cases andcontrols. Our results suggest that an altered regulation in transcription initiation maybe an important mechanism for low RGS4 protein levels in Alzeimer’s disease. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 653 | a neurodegeneration | |
| 653 | a RGS splice variants | |
| 653 | a SNP | |
| 653 | a real-time RT-PCR | |
| 653 | a Biology | |
| 653 | a Biologi | |
| 700 | 1 | a Saetre, Peteru Uppsala universitet,Zoologisk utvecklingsbiologi,beteende genetik4 aut |
| 700 | 1 | a Jazin, Elenau Uppsala universitet,Zoologisk utvecklingsbiologi4 aut0 (Swepub:uu)elenjazi |
| 710 | 2 | a Uppsala universitetb Zoologisk utvecklingsbiologi4 org |
| 773 | 0 | t Synapseg 59:3, s. 173-176q 59:3<173-176x 0887-4476x 1098-2396 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-93408 |
| 856 | 4 8 | u https://doi.org/10.1002/SYN.20226 |
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