Sökning: L773:1438 4639 OR L773:1618 131X >
Polybrominated diph...
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Charles, DolleyDepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway
(författare)
Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls : Repeated measurements prior to and after diagnosis
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Elsevier,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-205784
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205784URI
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https://doi.org/10.1016/j.ijheh.2023.114148DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between PBDEs and T2DM. No longitudinal studies have assessed associations between repeated measurements of PBDE and T2DM in the same individuals and compared time trends of PBDEs in T2DM cases and controls.Objectives: To investigate associations between pre- and post-diagnostic measurements of PBDEs and T2DM and to compare time trends of PBDEs in T2DM cases and controls.Methods: Questionnaire data and serum samples from participants in the Tromsø Study were used to conduct a longitudinal nested case-control study among 116 T2DM cases and 139 controls. All included study participants had three pre-diagnostic blood samples (collected before T2DM diagnosis in cases), and up to two post-diagnostic samples after T2DM diagnosis. We used logistic regression models to investigate pre- and post-diagnostic associations between PBDEs and T2DM, and linear mixed-effect models to assess time trends of PBDEs in T2DM cases and controls.Results: We observed no substantial pre- or post-diagnostic associations between any of the PBDEs and T2DM, except for BDE-154 at one of the post-diagnostic time-points (OR = 1.65, 95% CI: 1.00, 2.71). The overall time trends of PBDE concentrations were similar for cases and controls.Discussion: The study did not support PBDEs increasing the odds of T2DM, prior to or after T2DM diagnosis. T2DM status did not influence the time trends of PBDE concentrations.
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Berg, VivianDepartment of Medical Biology, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway; Department of Laboratory Medicine, Division of Diagnostic Services, University Hospital of North Norway, Tromsø, Norway
(författare)
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Nøst, Therese HaugdahlDepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway; Department of Community Medicine and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
(författare)
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Wilsgaard, TomDepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway
(författare)
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Bergdahl, IngvarUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)inbe0001
(författare)
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Huber, SandraDepartment of Laboratory Medicine, Division of Diagnostic Services, University Hospital of North Norway, Tromsø, Norway
(författare)
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Ayotte, PierreDepartment of Social and Preventive Medicine, Laval University, QC, Québec, Canada; Centre de Toxicologie du Québec, INSPQ, QC, Québec, Canada
(författare)
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Averina, MariaDepartment of Laboratory Medicine, Division of Diagnostic Services, University Hospital of North Norway, Tromsø, Norway; Department of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway
(författare)
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Sandanger, TorkjelDepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway; NILU-Norwegian Institute for Air Research, Tromsø, Norway
(författare)
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Rylander, CharlottaDepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway
(författare)
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Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, NorwayDepartment of Medical Biology, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway; Department of Laboratory Medicine, Division of Diagnostic Services, University Hospital of North Norway, Tromsø, Norway
(creator_code:org_t)
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Ingår i:International journal of hygiene and environmental health: Elsevier2491438-46391618-131X
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Charles, Dolley
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Berg, Vivian
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Nøst, Therese Ha ...
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Wilsgaard, Tom
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Bergdahl, Ingvar
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Huber, Sandra
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Ayotte, Pierre
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Averina, Maria
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