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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05103naa a2201165 4500 | |
| 001 | oai:DiVA.org:kth-267921 | |
| 003 | SwePub | |
| 008 | 200402s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:142824114 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2679212 URI |
| 024 | 7 | a https://doi.org/10.1038/s41551-019-0497-x2 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1428241142 URI |
| 040 | a (SwePub)kthd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Novak, R.4 aut |
| 245 | 1 0 | a Robotic fluidic coupling and interrogation of multiple vascularized organ chips |
| 264 | c 2020-01-27 | |
| 264 | 1 | b Nature Research,c 2020 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20200402 | |
| 520 | a Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an ‘interrogator’ that employs liquid-handling robotics, custom software and an integrated mobile microscope for the automated culture, perfusion, medium addition, fluidic linking, sample collection and in situ microscopy imaging of up to ten organ chips inside a standard tissue-culture incubator. The robotic interrogator maintained the viability and organ-specific functions of eight vascularized, two-channel organ chips (intestine, liver, kidney, heart, lung, skin, blood–brain barrier and brain) for 3 weeks in culture when intermittently fluidically coupled via a common blood substitute through their reservoirs of medium and endothelium-lined vascular channels. We used the robotic interrogator and a physiological multicompartmental reduced-order model of the experimental system to quantitatively predict the distribution of an inulin tracer perfused through the multi-organ human-body-on-chips. The automated culture system enables the imaging of cells in the organ chips and the repeated sampling of both the vascular and interstitial compartments without compromising fluidic coupling. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a Blood | |
| 653 | a Physiological models | |
| 653 | a Tissue culture | |
| 653 | a Culture systems | |
| 653 | a Experimental system | |
| 653 | a In-situ microscopies | |
| 653 | a Liquid handling | |
| 653 | a Organ systems | |
| 653 | a Reduced order models | |
| 653 | a Sample collection | |
| 653 | a Vascular perfusion | |
| 653 | a Robotics | |
| 700 | 1 | a Ingram, M.4 aut |
| 700 | 1 | a Marquez, S.4 aut |
| 700 | 1 | a Das, D.4 aut |
| 700 | 1 | a Delahanty, A.4 aut |
| 700 | 1 | a Herland, Annau Karolinska Institutet,KTH,Mikro- och nanosystemteknik4 aut0 (Swepub:kth)u1koqi31 |
| 700 | 1 | a Maoz, B. M.4 aut |
| 700 | 1 | a Jeanty, S. S. F.4 aut |
| 700 | 1 | a Somayaji, M. R.4 aut |
| 700 | 1 | a Burt, M.4 aut |
| 700 | 1 | a Calamari, E.4 aut |
| 700 | 1 | a Chalkiadaki, A.4 aut |
| 700 | 1 | a Cho, A.4 aut |
| 700 | 1 | a Choe, Y.4 aut |
| 700 | 1 | a Chou, D. B.4 aut |
| 700 | 1 | a Cronce, M.4 aut |
| 700 | 1 | a Dauth, S.4 aut |
| 700 | 1 | a Divic, T.4 aut |
| 700 | 1 | a Fernandez-Alcon, J.4 aut |
| 700 | 1 | a Ferrante, T.4 aut |
| 700 | 1 | a Ferrier, J.4 aut |
| 700 | 1 | a FitzGerald, E. A.4 aut |
| 700 | 1 | a Fleming, R.4 aut |
| 700 | 1 | a Jalili-Firoozinezhad, S.4 aut |
| 700 | 1 | a Grevesse, T.4 aut |
| 700 | 1 | a Goss, J. A.4 aut |
| 700 | 1 | a Hamkins-Indik, T.4 aut |
| 700 | 1 | a Henry, O.4 aut |
| 700 | 1 | a Hinojosa, C.4 aut |
| 700 | 1 | a Huffstater, T.4 aut |
| 700 | 1 | a Jang, K. -J4 aut |
| 700 | 1 | a Kujala, V.4 aut |
| 700 | 1 | a Leng, L.4 aut |
| 700 | 1 | a Mannix, R.4 aut |
| 700 | 1 | a Milton, Y.4 aut |
| 700 | 1 | a Nawroth, J.4 aut |
| 700 | 1 | a Nestor, B. A.4 aut |
| 700 | 1 | a Ng, C. F.4 aut |
| 700 | 1 | a O’Connor, B.4 aut |
| 700 | 1 | a Park, T. -E4 aut |
| 700 | 1 | a Sanchez, H.4 aut |
| 700 | 1 | a Sliz, J.4 aut |
| 700 | 1 | a Sontheimer-Phelps, A.4 aut |
| 700 | 1 | a Swenor, B.4 aut |
| 700 | 1 | a Thompson, G. , I I4 aut |
| 700 | 1 | a Touloumes, G. J.4 aut |
| 700 | 1 | a Tranchemontagne, Z.4 aut |
| 700 | 1 | a Wen, N.4 aut |
| 700 | 1 | a Yadid, M.4 aut |
| 700 | 1 | a Bahinski, A.4 aut |
| 700 | 1 | a Hamilton, G. A.4 aut |
| 700 | 1 | a Levner, D.4 aut |
| 700 | 1 | a Levy, O.4 aut |
| 700 | 1 | a Przekwas, A.4 aut |
| 700 | 1 | a Prantil-Baun, R.4 aut |
| 700 | 1 | a Parker, K. K.4 aut |
| 700 | 1 | a Ingber, D. E.4 aut |
| 710 | 2 | a KTHb Mikro- och nanosystemteknik4 org |
| 773 | 0 | t Nature Biomedical Engineeringd : Nature Researchx 2157-846X |
| 856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057865 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-267921 |
| 856 | 4 8 | u https://doi.org/10.1038/s41551-019-0497-x |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142824114 |
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