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FältnamnIndikatorerMetadata
00010354naa a2200913 4500
001oai:DiVA.org:uu-368367
003SwePub
008181204s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3683672 URI
0247 a https://doi.org/10.1016/j.eururo.2018.07.0242 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Watts, Eleanor L.u Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England4 aut
2451 0a Low Free Testosterone and Prostate Cancer Risk :b A Collaborative Analysis of 20 Prospective Studies
264 1b Elsevier,c 2018
338 a electronic2 rdacarrier
520 a Background: Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. Objective: To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Design, setting, and participants: Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Outcome measurements and statistical analysis: Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Results and limitations: Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR = 0.77, 95% confidence interval [CI] 0.69-0.86; p < 0.001) compared with men with higher concentrations (2nd-10th tenths of the distribution). Heterogeneity was present by tumour grade (p(het) = 0.01), with a lower risk of low-grade disease (OR = 0.76, 95% CI 0.67-0.88) and a nonsignificantly higher risk of high-grade disease (OR = 1.56, 95% CI 0.95-2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Conclusions: Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. Patient summary: In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer. (c) 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a Androgens Pooled analysis
653 a Prospective studies
653 a Prostate cancer
653 a Sex hormones
653 a Testosterone
653 a Epidemiology
7001 a Appleby, Paul N.u Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England4 aut
7001 a Perez-Cornago, Aurorau Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England4 aut
7001 a Bueno-de-Mesquita, H. Basu Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis, Bilthoven, Netherlands;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands;Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Malaya, Dept Social & Prevent Med, Kuala Lumpur, Malaysia4 aut
7001 a Chan, June M.u Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Urol, San Francisco, CA USA4 aut
7001 a Chen, Chuu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA4 aut
7001 a Cohn, Barbara A.u Publ Hlth Inst, Child Hlth & Dev Studies, Berkeley, CA USA4 aut
7001 a Cook, Michael B.u US Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA4 aut
7001 a Flicker, Leonu Univ Western Australia, Sch Med, Perth, WA, Australia;Univ Western Australia, Med Res Ctr, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia4 aut
7001 a Freedman, Neal D.u US Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA4 aut
7001 a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia4 aut
7001 a Giovannucci, Edwardu Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA;Publ Hlth Directorate, Asturias, Spain;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA4 aut
7001 a Gislefoss, Randi E.u Inst Epidemiol Canc Res, Canc Registry Norway, Oslo, Norway4 aut
7001 a Hankey, Graeme J.u Univ Western Australia, Sch Med, Perth, WA, Australia4 aut
7001 a Kaaks, Rudolfu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany4 aut
7001 a Knekt, Paulu Natl Inst Hlth & Welf, Helsinki, Finland4 aut
7001 a Kolonel, Laurence N.u Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA4 aut
7001 a Kubo, Tatsuhikou Univ Occupat & Environm Hlth, Dept Prevent Med & Community Hlth, Kitakyushu, Fukuoka, Japan4 aut
7001 a Le Marchand, Loicu Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA4 aut
7001 a Luben, Robert N.u Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England4 aut
7001 a Luostarinen, Tapiou Inst Stat & Epidemiol Canc Res, Finnish Canc Registry, Helsinki, Finland4 aut
7001 a Mannisto, Satuu Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland4 aut
7001 a Metter, E. Jeffreyu Univ Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA4 aut
7001 a Mikami, Kazuyau Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Urol, Kyoto, Japan4 aut
7001 a Milne, Roger L.u Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia4 aut
7001 a Ozasa, Kotarou Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan4 aut
7001 a Platz, Elizabeth A.u Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA4 aut
7001 a Quiros, J. Ramonu Publ Hlth Directorate, Asturias, Spain4 aut
7001 a Rissanen, Harriu Natl Inst Hlth & Welf, Helsinki, Finland4 aut
7001 a Sawada, Norieu Natl Canc Ctr, Epidemiol & Prevent Grp, Ctr Publ Hlth Sci, Tokyo, Japan4 aut
7001 a Stampfer, Meiru Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA4 aut
7001 a Stanczyk, Frank Z.u Univ Southern Calif, Keck Sch Med, Div Reprod Endocrinol & Infertil, Los Angeles, CA USA4 aut
7001 a Stattin, Päru Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)parst892
7001 a Tamakoshi, Akikou Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Sapporo, Hokkaido, Japan4 aut
7001 a Tangen, Catherine M.u Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA4 aut
7001 a Thompson, Ian M.u Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA4 aut
7001 a Tsilidis, Konstantinos K.u Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece4 aut
7001 a Tsugane, Shoichirou Natl Canc Ctr, Epidemiol & Prevent Grp, Ctr Publ Hlth Sci, Tokyo, Japan4 aut
7001 a Ursin, Giskeu Inst Epidemiol Canc Res, Canc Registry Norway, Oslo, Norway;Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway;Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA4 aut
7001 a Vatten, Larsu Norwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth, Trondheim, Norway4 aut
7001 a Weiss, Noel S.u Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA4 aut
7001 a Yeap, Bu B.u Univ Western Australia, Sch Med, Perth, WA, Australia;Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia4 aut
7001 a Allen, Naomi E.u Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England4 aut
7001 a Key, Timothy J.u Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England4 aut
7001 a Travis, Ruth C.u Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England4 aut
7102 a Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, Englandb Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis, Bilthoven, Netherlands;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands;Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Malaya, Dept Social & Prevent Med, Kuala Lumpur, Malaysia4 org
7730 t European Urologyd : Elsevierg 74:5, s. 585-594q 74:5<585-594x 0302-2838x 1873-7560
8564 u https://doi.org/10.1016/j.eururo.2018.07.024y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1268032/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.eururo.2018.07.024
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368367
8564 8u https://doi.org/10.1016/j.eururo.2018.07.024

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