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Associations of PFA...
Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations
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- Schillemans, Tessa (författare)
- Karolinska Institutet
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- Bergdahl, Ingvar (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå University
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- Hanhineva, Kati, 1972 (författare)
- Itä-Suomen Yliopisto,University of Eastern Finland,Chalmers tekniska högskola,Chalmers University of Technology,Turun Yliopisto,University of Turku,Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; Department of Life Technologies, University of Turku, Turku, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Shi, Lin, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Shaanxi Normal University,Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’ an, China
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- Donat Vargas, Carolina (författare)
- Karolinska Institutet
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- Koponen, Jani (författare)
- Department for Health Security, Environmental Health Unit, Finnish Institute for Health and Welfare, Kuopio, Finland
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- Kiviranta, Hannu (författare)
- Department for Health Security, Environmental Health Unit, Finnish Institute for Health and Welfare, Kuopio, Finland
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- Landberg, Rikard, 1981 (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden,Umeå University,Chalmers tekniska högskola,Chalmers University of Technology
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- Åkesson, Agneta (författare)
- Karolinska Institutet
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- Brunius, Carl, 1974 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 216
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://research.cha...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The wide-spread environmental pollutants per- and polyfluoroalkyl substances (PFAS) have repeatedly been associated with elevated serum cholesterol in humans. However, underlying mechanisms are still unclear. Furthermore, we have previously observed inverse associations with plasma triglycerides. To better understand PFAS-induced effects on lipid pathways we investigated associations of PFAS-related metabolite features with plasma cholesterol and triglyceride concentrations. We used 290 PFAS-related metabolite features that we previously discovered from untargeted liquid chromatography-mass spectometry metabolomics in a case-control study within the Swedish Västerbotten Intervention Programme cohort. Herein, we studied associations of these PFAS-related metabolite features with plasma cholesterol and triglyceride concentrations in plasma samples from 187 healthy control subjects collected on two occasions between 1991 and 2013. The PFAS-related features did not associate with cholesterol, but 50 features were associated with triglycerides. Principal component analysis on these features indicated that one metabolite pattern, dominated by glycerophospholipids, correlated with longer chain PFAS and associated inversely with triglycerides (both cross-sectionally and prospectively), after adjustment for confounders. The observed time-trend of the metabolite pattern resembled that of the longer chain PFAS, with higher levels during the years 2004–2010. Mechanisms linking PFAS exposures to triglycerides may thus occur via longer chain PFAS affecting glycerophospholipid metabolism. If the results reflect a cause-effect association, as implied by the time-trend and prospective analyses, this may affect the general adult population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Per- and polyfluoroalkyl substances
- HBM4EU
- Metabolomics
- Triglycerides
- Cholesterol
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Schillemans, Tes ...
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Bergdahl, Ingvar
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Hanhineva, Kati, ...
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Shi, Lin, 1988
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Donat Vargas, Ca ...
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Koponen, Jani
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visa fler...
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Kiviranta, Hannu
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Landberg, Rikard ...
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Åkesson, Agneta
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Brunius, Carl, 1 ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Annan klinisk me ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Environmental Re ...
- Av lärosätet
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Chalmers tekniska högskola
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Umeå universitet
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Karolinska Institutet