The Effect of Thyroid Dysfunction on Plasma Creatinine Levels

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Fältnamn	Indikatorer	Metadata
000		03129naa a2200325 4500
001		oai:DiVA.org:uu-309536
003		SwePub
008		161205s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3095362 URI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Englund Flodström, Iu Department of Medical Biosciences, Umeå University,4 aut
245	1 0	a The Effect of Thyroid Dysfunction on Plasma Creatinine Levels
264	1	c 2016
338		a print2 rdacarrier
520		a Introduction: There are conflicting reports on how kidney function isaffected in patients with thyroid dysfunction. This study was designed toinvestigate how hypothyroidism and hyperthyroidism affect the concentration ofplasma creatinine in a large patient material.Methods: Patient results with simultaneous determinations of FT4, FT3,TSH and creatinine were extracted from the laboratory information system. Overan eight year period this yielded more than thousand cases with results fromthyroid function tests combined with plasma creatinine concentrations.Results: Median plasma levels of creatinine differed significantly inhypothyroid and hyperthyroid patients as compared to euthyroid controls.An approximate 20% increase and decrease in median plasma creatinineconcentration was found for hypothyroid and hyperthyroid patients, respectively.The differences were statistically significant (p<0.001) for both groups and stillso when divided according to gender. A correlation analysis showed a significantnegative correlation between the biologically active freeT3 and creatinine.Conclusion: Thyroid hormone correlates significantly to plasma creatinine.It is important to be aware of the relationship between thyroid function andkidney function when interpreting plasma creatinine results and to considerhypothyroidism or hyperthyroidism as a possible cause of an abnormal plasmacreatinine level.Further research is needed in order to uncover the mechanisms behi
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Berggren, Karlu Department of Laboratory Medicine, Unilabs, Sweden4 aut
700	1	a Usener, Bu Department of Laboratory Medicine, Unilabs, Sweden4 aut
700	1	a Broberg, Hu Department of Laboratory Medicine, Unilabs, Sweden4 aut
700	1	a Larsson, Andersu Uppsala universitet,Biokemisk struktur och funktion4 aut0 (Swepub:uu)andlarss
700	1	a Brattsand, Göranu Department of Medical Biosciences, Umeå University,4 aut
710	2	a Department of Medical Biosciences, Umeå University,b Department of Laboratory Medicine, Unilabs, Sweden4 org
773	0	t Annals of Thyroid Researchg 2:2, s. 82-86q 2:2<82-86
856	4	u http://austinpublishinggroup.com/december-2016/published-articles-2.php
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-309536

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Av författaren/redakt...: Englund Flodströ ...; Berggren, Karl; Usener, B; Broberg, H; Larsson, Anders; Brattsand, Göran

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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