Anti-müllerian hormone levels are associated with live birth rates in ART, but the predictive ability of anti-müllerian hormone is modest

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Fältnamn	Indikatorer	Metadata
000		04355naa a2200361 4500
001		oai:lup.lub.lu.se:7c45485e-3137-4da6-bc13-52c7f353a71a
003		SwePub
008		180521s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/7c45485e-3137-4da6-bc13-52c7f353a71a2 URI
024	7	a https://doi.org/10.1016/j.ejogrb.2018.04.0392 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Alson, Sara S.E.u Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)sa7721al
245	1 0	a Anti-müllerian hormone levels are associated with live birth rates in ART, but the predictive ability of anti-müllerian hormone is modest
264	1	b Elsevier BV,c 2018
300		a 6 s.
520		a Objectives: The aim was to evaluate the association between serum Anti-Müllerian Hormone (AMH) level and cumulative live birth rates (LBR) in patients undergoing their first in vitro fertilization (IVF) treatment cycle, and to compare serum AMH levels with Antral Follicle Count (AFC) and Ovarian Sensitivity Index (OSI) as predictors of live birth. Study design: A prospective cohort study of 454 patients under the age of 40 and with a regular menstrual cycle of 21-35 days, undergoing their first IVF treatment cycles between September 2010 and June 2015. Participants were divided into three groups based on their AMH level, (AMH ≤10, AMH 10-<30 and AMH ≥30 pmol/l). Any difference in AMH-distribution between patients with or without live birth was analyzed using a Mann-Whitney-test, and live birth rates were compared between groups by a chi-squared test for linear trend. The ability of AMH, OSI and AFC as predictors of live birth was assessed by a receiver operating characteristics-analysis and the area under the curve (AUC) was calculated. Results: Patients with live birth had a higher AMH, median (range) 26 [0-137] pmol/l, compared with patients without live birth, AMH 22 [0-154] pmol/l, p = 0.035. Mean live birth rate (SD) was 0.36 (0.48) in the total cohort, 0.26 (0.44) in AMH-group <10, 0.34 (0.48) in AMH-group 10-<30, and 0.41(0.49) in AMH-group ≥30. Thus live birth rates increased with 8% per AMH-group (95% CI: 0.02 −0.14, p = 0.015). The AUC for AFC was 0.56, for AMH 0.57 and for OSI 0.63, respectively. Conclusion: AMH concentration in serum is associated with live birth rates after IVF. Our results suggest that both AMH, AFC and OSI have an equal but modest predictive ability in relation to live birth rate.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653		a Anti-müllerian hormone
653		a Live birth
653		a Ovarian sensitivity index
700	1	a Bungum, Leif J.u Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-lbu
700	1	a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-agi
700	1	a Henic, Emiru Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)em2131he
710	2	a Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostikb Forskargrupper vid Lunds universitet4 org
773	0	t European Journal of Obstetrics, Gynecology, and Reproductive Biologyd : Elsevier BVg 225, s. 199-204q 225<199-204x 0301-2115
856	4	u http://dx.doi.org/10.1016/j.ejogrb.2018.04.039y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/7c45485e-3137-4da6-bc13-52c7f353a71a
856	4 8	u https://doi.org/10.1016/j.ejogrb.2018.04.039

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Av författaren/redakt...: Alson, Sara S.E.; Bungum, Leif J.; Giwercman, Aleks ...; Henic, Emir

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

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Av lärosätet: Lunds universitet

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