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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008152naa a2201021 4500
001oai:lup.lub.lu.se:6ddb9392-66a3-47fe-8507-d086dce1b12a
003SwePub
008210112s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-431727
009oai:prod.swepub.kib.ki.se:145707735
0247 a https://lup.lub.lu.se/record/6ddb9392-66a3-47fe-8507-d086dce1b12a2 URI
0247 a https://doi.org/10.1038/s41467-020-17359-22 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4317272 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1457077352 URI
040 a (SwePub)lud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Li, Constance H.u University of Toronto,University of California, Los Angeles,Ontario Institute for Cancer Research4 aut
2451 0a Sex differences in oncogenic mutational processes
264 c 2020-08-28
264 1b Springer Science and Business Media LLC,c 2020
300 a 24 s.
500 a CW deltog i PCAWG Consortium. 
520 a Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Prokopec, Stephenie D.u Ontario Institute for Cancer Research4 aut
7001 a Sun, Ren X.u University of Toronto,Ontario Institute for Cancer Research4 aut
7001 a Yousif, Fouadu Ontario Institute for Cancer Research4 aut
7001 a Schmitz, Nathanielu Ontario Institute for Cancer Research4 aut
7001 a Al-Shahrour, Fatimau Spanish National Cancer Research Center (CNIO)4 aut
7001 a Atwal, Gurnitu University of Toronto,Ontario Institute for Cancer Research4 aut
7001 a Bailey, Peter J.u Glasgow Royal Infirmary4 aut
7001 a Biankin, Andrew V.u Glasgow Royal Infirmary,University of New South Wales4 aut
7001 a Boutros, Paul C.u University of California, Los Angeles,Ontario Institute for Cancer Research,University of Toronto4 aut
7001 a Campbell, Peter J.u University of Cambridge,Wellcome Trust Sanger Institute4 aut
7001 a Chang, David K.u Glasgow Royal Infirmary,University of New South Wales4 aut
7001 a Cooke, Susanna L.u Glasgow Royal Infirmary4 aut
7001 a Deshpande, Vikramu Massachusetts General Hospital4 aut
7001 a Faltas, Bishoy M.u Weill Cornell Medical College4 aut
7001 a Faquin, William C.u Massachusetts General Hospital4 aut
7001 a Garraway, Leviu Dana-Farber Cancer Institute4 aut
7001 a Getz, Gadu Massachusetts General Hospital,Broad Institute,Harvard Medical School4 aut
7001 a Grimmond, Sean M.u University of Melbourne4 aut
7001 a Haider, Syedu Ontario Institute for Cancer Research4 aut
7001 a Hoadley, Katherine A.u University of North Carolina4 aut
7001 a Jiao, Weiu Ontario Institute for Cancer Research4 aut
7001 a Kaiser, Vera B.u University of Edinburgh4 aut
7001 a Karlić, Rosau University of Zagreb4 aut
7001 a Kato, Mamoruu National Cancer Center Research Institute, Japan4 aut
7001 a Kübler, Kirstenu Massachusetts General Hospital,Harvard Medical School,Broad Institute4 aut
7001 a Lazar, Alexander J.u University of Texas4 aut
7001 a Wright, Derek W.u University of Glasgow4 aut0 (Swepub:lu)mbio-dwr
7001 a Borg, Akeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)onk-abo
7001 a Davis, Ian J.u University of North Carolina4 aut0 (Swepub:lu)bran-iad
7001 a Ehinger, Annau Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)pat-amm
7001 a Glodzik, Dominiku Wellcome Trust Sanger Institute4 aut0 (Swepub:lu)do5123gl
7001 a Grabau, Dortheu Skåne University Hospital4 aut0 (Swepub:lu)med-dgu
7001 a Huang, Mi Niu Duke–NUS Medical School4 aut0 (Swepub:lu)hu7785mi
7001 a Johansson, Peter A.u QIMR Berghofer Medical Research Institute4 aut
7001 a Larsson, Eriku University of Gothenburg4 aut
7001 a Li, Changu China National Genebank4 aut
7001 a Li, Haiyan Ireneu British Columbia Cancer Agency4 aut0 (Swepub:lu)endo-hli
7001 a Li, Junu University of Texas4 aut
7001 a Möller, Peteru University Hospital of Ulm4 aut
7001 a Ringnér, Markusu Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)thep-mri
7001 a Song, Leiu National Cancer Institute, USA4 aut0 (Swepub:lu)med-ls1
7001 a Staaf, Johanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Institutionen för kliniska vetenskaper, Lund,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)onk-jst
7001 a Wang, Jian4 aut
7001 a Wang, Qiu German Cancer Research Centre4 aut
7001 a Yang, Yangu University of Texas4 aut
7001 a Zhang, Fanu Peking University4 aut
7001 a Zhang, Jingu Yale University4 aut
7001 a Zhang, Yanu Yale University,Ohio State University4 aut
7102 a University of Torontob University of California, Los Angeles4 org
7102 a PCAWG Tumour Subtypes and Clinical Translation
7102 a PCAWG Consortium
7730 t Nature Communicationsd : Springer Science and Business Media LLCg 11q 11x 2041-1723
8564 u http://dx.doi.org/10.1038/s41467-020-17359-2x freey FULLTEXT
8564 u https://www.nature.com/articles/s41467-020-17359-2.pdf
8564 8u https://lup.lub.lu.se/record/6ddb9392-66a3-47fe-8507-d086dce1b12a
8564 8u https://doi.org/10.1038/s41467-020-17359-2
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431727
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145707735

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