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Sökning: WFRF:(Chernogubova Ekaterina) > The one-carbon pool...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003866naa a2200589 4500
001oai:DiVA.org:kth-291898
003SwePub
008210323s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:145917430
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2918982 URI
0247 a https://doi.org/10.1126/sciadv.abf07172 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1459174302 URI
040 a (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Schober, Florian A.u Karolinska Institutet4 aut
2451 0a The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters
264 1b American Association for the Advancement of Science (AAAS),c 2021
338 a print2 rdacarrier
500 a QC 20210323
520 a Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains unclear how one-carbon availability connects to mitochondrial function. Here, we show that the one-carbon metabolite and methyl group donor S-adenosylmethionine (SAM) is pivotal for energy metabolism. A gradual decline in mitochondrial SAM (mitoSAM) causes hierarchical defects in fly and mouse, comprising loss of mitoSAM-dependent metabolites and impaired assembly of the oxidative phosphorylation system. Complex I stability and iron-sulfur cluster biosynthesis are directly controlled by mitoSAM levels, while other protein targets are predominantly methylated outside of the organelle before import. The mitoSAM pool follows its cytosolic production, establishing mitochondria as responsive receivers of one-carbon units. Thus, we demonstrate that cellular methylation potential is required for energy metabolism, with direct relevance for pathophysiology, aging, and cancer.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
7001 a Moore, David4 aut
7001 a Atanassov, Ilian4 aut
7001 a Moedas, Marco F.u Karolinska Institutet4 aut
7001 a Clemente, Paulau Karolinska Institutet4 aut
7001 a Vegvari, Akosu Karolinska Institutet4 aut
7001 a El Fissi, Najla4 aut
7001 a Filograna, Robertau Karolinska Institutet4 aut
7001 a Bucher, Anna-Lena4 aut
7001 a Hinze, Yvonne4 aut
7001 a The, Matthewu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1c6xiyk
7001 a Hedman, Erik4 aut
7001 a Chernogubova, Ekaterinau Karolinska Institutet4 aut
7001 a Begzati, Arjana4 aut
7001 a Wibom, Rolfu Karolinska Institutet4 aut
7001 a Jain, Mohit4 aut
7001 a Nilsson, Rolandu Karolinska Institutet4 aut
7001 a Käll, Lukas,d 1969-u KTH,Science for Life Laboratory, SciLifeLab,Genteknologi4 aut0 (Swepub:kth)u1gqsept
7001 a Wedell, Annau Karolinska Institutet4 aut
7001 a Freyer, Christophu Karolinska Institutet4 aut
7001 a Wredenberg, Annau Karolinska Institutet4 aut
7102 a Karolinska Institutetb Science for Life Laboratory, SciLifeLab4 org
7730 t Science Advancesd : American Association for the Advancement of Science (AAAS)g 7:8q 7:8x 2375-2548
8564 u https://doi.org/10.1126/sciadv.abf0717y Fulltext
8564 u https://www.science.org/doi/pdf/10.1126/sciadv.abf0717?download=true
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291898
8564 8u https://doi.org/10.1126/sciadv.abf0717
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145917430

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