Sökning: WFRF:(Erdogan F) > Genome-wide associa...
Fältnamn | Indikatorer | Metadata |
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000 | 04975naa a2200673 4500 | |
001 | oai:hhs.se:1155078830006056 | |
003 | SwePub | |
008 | 221125s2017 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:136091607 | |
024 | 7 | a https://research.hhs.se/esploro/outputs/journalArticle/Genome-wide-association-meta-analysis-of-78308-individuals/9910014805699060562 URI |
024 | 7 | a https://doi.org/10.1038/ng.38692 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360916072 URI |
040 | a (SwePub)hhsd (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Johannesson, Magnusu Stockholm School of Economics,Handelshögskolan i Stockholm4 aut0 (Swepub:hhs)198@hhs.se |
245 | 1 0 | a Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence |
264 | c 2017-05-22 | |
264 | 1 | b Nature Research (part of Springer Nature),c 2017 |
520 | a Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P −8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P −6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10−6). Despite the well-known difference in twin-based heritability2 for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10−29). These findings provide new insight into the genetic architecture of intelligence. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Cesarini, Davidu Center for Experimental Social Science4 aut |
700 | 1 | a Koellinger, Philipp D.u Erasmus School of Economics (NL)4 aut |
700 | 1 | a Magnusson, Patrik K. E.u Karolinska Institutet,Karolinska Institutet (SE),King's College London (GB)4 aut |
700 | 1 | a Okbay, Aysuu Erasmus School of Economics (NL)4 aut |
700 | 1 | a Rietveld, Cornelius A.u Erasmus University (NL)4 aut |
700 | 1 | a Tiemeier, Henningu Erasmus University (NL)4 aut |
700 | 1 | a Sniekers, Suzanneu VU University (NL)4 aut |
700 | 1 | a Stringer, Svenu VU University (NL)4 aut |
700 | 1 | a Watanabe, Kyokou VU University (NL)4 aut |
700 | 1 | a Jansen, Phillip R.u VU University (NL)4 aut |
700 | 1 | a Coleman, Jonathan R. I.u King's College London (GB)4 aut |
700 | 1 | a Krapohl, Evau King's College London (GB)4 aut |
700 | 1 | a Taskesen, Erdoganu VU University (NL)4 aut |
700 | 1 | a Hammerschlag, Anke R.u VU University (NL)4 aut |
700 | 1 | a Zabaneh, Delilahu King's College London (GB)4 aut |
700 | 1 | a Amin, Najafu Erasmus Medical Center4 aut |
700 | 1 | a Breen, Geromeu National institute of health research4 aut |
700 | 1 | a Chabris, Christopher F.u Union College (US)4 aut |
700 | 1 | a Iacono, William G.u University of Minnesota Twin Cities (US)4 aut |
700 | 1 | a Ikram, Arfan M.u Erasmus Medical Center,University of Minnesota Twin Cities (US)4 aut |
700 | 1 | a Lee, James J.u University of Minnesota Twin Cities (US)4 aut |
700 | 1 | a McGue, Mattu University of Minnesota Twin Cities (US),Leiden University4 aut |
700 | 1 | a Miller, Mike B.u University of Minnesota Twin Cities (US)4 aut |
700 | 1 | a Ollier, William E.R.u University of Manchester (GB)4 aut |
700 | 1 | a Payton, Antonyu University of Manchester (GB)4 aut |
700 | 1 | a Pendleton, Neilu University of Manchester (GB)4 aut |
700 | 1 | a Plomin, Robertu King's College London (GB)4 aut |
700 | 1 | a van Duijn, Cornerlia M.u Leiden University4 aut |
700 | 1 | a Posthuma, Danielleu VU University (NL)4 aut |
710 | 2 | a Handelshögskolan i Stockholmb Stockholm School of Economics4 org |
773 | 0 | t Nature Geneticsd : Nature Research (part of Springer Nature)x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc5665562?pdf=render |
856 | 4 8 | u https://research.hhs.se/esploro/outputs/journalArticle/Genome-wide-association-meta-analysis-of-78308-individuals/991001480569906056 |
856 | 4 8 | u https://doi.org/10.1038/ng.3869 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:136091607 |
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