Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women

Almanza-Aguilera, EnriqueUniversitat de Barcelona,University of Barcelona,Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII) (författare)

Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism.

Brunius, Carl,1974Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science,Chalmers University of Technology(Swepub:slu)48489 (författare)
Bernal-Lopez, M. RosaInstituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII) (författare)
Garcia-Aloy, MarInstituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII),Universitat de Barcelona,University of Barcelona (författare)
Madrid-Gambin, FranciscoInstituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII),Universitat de Barcelona,University of Barcelona (författare)
Tinahones, Francisco J.Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII) (författare)
Gómez-Huelgas, RicardoInstituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII) (författare)
Landberg, Rikard,1981Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science,Chalmers University of Technology(Swepub:slu)51036 (författare)
Andres-Lacueva, CristinaUniversitat de Barcelona,University of Barcelona,Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII) (författare)
Universitat de BarcelonaInstituto de Salud Carlos III (ISCIII) (creator_code:org_t)
Sveriges lantbruksuniversitet

Ingår i:Journal of Proteome Research: American Chemical Society (ACS)17:8, s. 2600-26101535-39071535-3893

Av författaren/redakt...: Almanza-Aguilera ...; Brunius, Carl, 1 ...; Bernal-Lopez, M. ...; Garcia-Aloy, Mar; Madrid-Gambin, F ...; Tinahones, Franc ...; visa fler...; Gómez-Huelgas, R ...; Landberg, Rikard ...; Andres-Lacueva, ...; visa färre...

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