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Human G-MDSCs are n...
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer
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- Mehmeti-Ajradini, Meliha (author)
- Lund Univ, Sweden
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- Bergenfelz, Caroline (author)
- Lund Univ, Sweden
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- Larsson, Anna-Maria (author)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Carlsson, Robert (author)
- Lund Univ, Sweden
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- Riesbeck, Kristian (author)
- Lund Univ, Sweden
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- Ahl, Jonas (author)
- Lund Univ, Sweden
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- Janols, Helena (author)
- Lund Univ, Sweden
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- Wullt, Marlene (author)
- Lund Univ, Sweden
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- Bredberg, Anders (author)
- Lund Univ, Sweden
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- Kallberg, Eva (author)
- Lund Univ, Sweden
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- Gunnarsdottir, Frida Bjork (author)
- Lund Univ, Sweden
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- Millrud, Camilla Rydberg (author)
- Lund Univ, Sweden
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- Ryden, Lisa (author)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Paul, Gesine (author)
- Lund Univ, Sweden
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- Loman, Niklas (author)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Adolfsson, Jörgen (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Carneiro, Ana (author)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Jirstrom, Karin (author)
- Lund Univ, Sweden
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- Killander, Fredrika (author)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Bexell, Daniel (author)
- Lund Univ, Sweden
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- Leandersson, Karin (author)
- Lund Univ, Sweden
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(creator_code:org_t)
- 2020-09-21
- 2020
- English.
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In: Life Science Alliance. - : LIFE SCIENCE ALLIANCE LLC. - 2575-1077. ; 3:11
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https://liu.diva-por... (primary) (Raw object)
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https://www.life-sci...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Myeloid-derived suppressor cells (MDSCs) are known to contribute to immune evasion in cancer. However, the function of the human granulocytic (G)-MDSC subset during tumor progression is largely unknown, and there are no established markers for their identification in human tumor specimens. Using gene expression profiling, mass cytometry, and tumor microarrays, we here demonstrate that human G-MDSCs occur as neutrophils at distinct maturation stages, with a disease-specific profile. G-MDSCs derived from patients with metastatic breast cancer and malignant melanoma display a unique immature neutrophil profile, that is more similar to healthy donor neutrophils than to G-MDSCs from sepsis patients. Finally, we show that primary G-MDSCs from metastatic breast cancer patients co-transplanted with breast cancer cells, promote tumor growth, and affect vessel formation, leading to myeloid immune cell exclusion. Our findings reveal a role for human G-MDSC in tumor progression and have clinical implications also for targeted immunotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mehmeti-Ajradini ...
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Bergenfelz, Caro ...
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Larsson, Anna-Ma ...
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Carlsson, Robert
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Riesbeck, Kristi ...
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Ahl, Jonas
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show more...
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Janols, Helena
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Wullt, Marlene
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Bredberg, Anders
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Kallberg, Eva
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Gunnarsdottir, F ...
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Millrud, Camilla ...
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Ryden, Lisa
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Paul, Gesine
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Loman, Niklas
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Adolfsson, Jörge ...
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Carneiro, Ana
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Jirstrom, Karin
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Killander, Fredr ...
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Bexell, Daniel
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Leandersson, Kar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Life Science All ...
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Linköping University