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WFRF:(Hagell A)
 

Sökning: WFRF:(Hagell A) > Health-related qual...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003670naa a2200421 4500
001oai:lup.lub.lu.se:d33e85bd-8c4e-4f6b-9e8b-b1738df51076
003SwePub
008160401s2000 | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/11170192 URI
024a https://doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Hagell, Peteru Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine4 aut0 (Swepub:lu)neur-pha
2451 0a Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease
264 1c 2000
520 a Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Parkinson's disease
653 a Transplantation
653 a Health-related quality of life
653 a Nottingham Health Profile
700a Crabb, L4 aut
700a Pogarell, O4 aut
700a Schrag, A4 aut
700a Widner, Håkanu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)mphy-hwi
700a Brooks, D J4 aut
700a Oertel, W H4 aut
700a Quinn, N P4 aut
700a Lindvall, Olleu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-oli
710a Institutionen för hälsovetenskaperb Medicinska fakulteten4 org
773t Movement Disordersg 15:2, s. 224-229q 15:2<224-229x 0885-3185
856u http://dx.doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-Wy FULLTEXT
8564 8u https://lup.lub.lu.se/record/1117019
8564 8u https://doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W

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