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WFRF:(Jess David Unnersjö)
 

Sökning: WFRF:(Jess David Unnersjö) > Deep learning-based...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005570naa a2200493 4500
001oai:DiVA.org:kth-330492
003SwePub
008230630s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:152888065
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3304922 URI
0247 a https://doi.org/10.1016/j.kint.2023.03.0132 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1528880652 URI
040 a (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jess, David Unnersjöu KTH,Biofysik,Science for Life Laboratory, SciLifeLab,Univ Cologne, Fac Med, Dept Internal Med 2, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany.;Karolinska Univ Hosp, MedTechLabs, Solna, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden.4 aut0 (Swepub:kth)u10c8quf
2451 0a Deep learning-based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies
264 1b Elsevier BV,c 2023
338 a print2 rdacarrier
500 a QC 20230630
520 a Morphological alterations at the kidney filtration barrier increase intrinsic capillary wall permeability resulting in albuminuria. However, automated, quantitative assessment of these morphological changes has not been possible with electron or light microscopy. Here we present a deep learning-based approach for segmentation and quantitative analysis of foot processes in images acquired with confocal and super-resolution fluorescence microscopy. Our method, Automatic Morphological Analysis of Podocytes (AMAP), accurately segments podocyte foot processes and quantifies their morphology. AMAP applied to a set of kidney diseases in patient biopsies and a mouse model of focal segmental glomerulosclerosis allowed for accurate and comprehensive quantification of various morphometric features. With the use of AMAP, detailed morphology of podocyte foot process effacement was found to differ between categories of kidney pathologies, showed detailed variability between diverse patients with the same clinical diagnosis, and correlated with levels of proteinuria. AMAP could potentially complement other readouts such as various omics, standard histologic/electron microscopy and blood/urine assays for future personalized diagnosis and treatment of kidney disease. Thus, our novel finding could have implications to afford an understanding of early phases of kidney disease progression and may provide supplemental information in precision diagnostics.
653 a artificial intelligence
653 a kidney pathology
653 a podocyte
7001 a Butt, Linusu Univ Cologne, Fac Med, Dept Internal Med 2, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany.;Univ Hosp Cologne, Dept Internal Med 2, Kerpener Str 62, D-50937 Cologne, Germany.4 aut
7001 a Hoehne, Martinu Univ Cologne, Fac Med, Dept Internal Med 2, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany.4 aut
7001 a Sergei, Germanu Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.4 aut
7001 a Fatehi, Arashu Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.4 aut
7001 a Witasp, Annau Karolinska Institutet4 aut
7001 a Wernerson, Annikau Karolinska Institutet4 aut
7001 a Patrakka, Jaakkou Karolinska Institutet4 aut
7001 a Hoyer, Peter F.u Univ Duisburg Essen, Pediat Nephrol, Pediat 2, Essen, Germany.4 aut
7001 a Blom, Hans,d 1968-u KTH,Science for Life Laboratory, SciLifeLab,Biofysik,Karolinska Univ Hosp, MedTechLabs, Solna, Sweden.4 aut0 (Swepub:kth)u1qhk3ta
7001 a Schermer, Bernhardu Univ Cologne, Fac Med, Dept Internal Med 2, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany.4 aut
7001 a Bozek, Katarzynau Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany.;Ctr Mol Med Cologne CMMC, Robert Koch Str 21, D-50931 Cologne, Germany.4 aut
7001 a Benzing, Thomasu Univ Cologne, Fac Med, Dept Internal Med 2, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respons, Cologne, Germany.4 aut
7102 a KTHb Biofysik4 org
7730 t Kidney Internationald : Elsevier BVg 103:6, s. 1120-1130q 103:6<1120-1130x 0085-2538x 1523-1755
8564 u https://doi.org/10.1016/j.kint.2023.03.013y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-330492
8564 8u https://doi.org/10.1016/j.kint.2023.03.013
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:152888065

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