Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS

Cardoso-Palacios, Carlos (författare): Uppsala universitet,Institutionen för kemi - BMC,Lanekoff group

Lanekoff, Ingela, Assoc. Prof. 1975- (författare): Uppsala universitet,Analytisk kemi,Lanekoff group

(creator_code:org_t)

Hindawi Limited, 2016
2016
Engelska.
Ingår i: Journal of Analytical Methods in Chemistry. - : Hindawi Limited. - 2090-8865 .- 2090-8873.

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Abstract Ämnesord

Stäng

Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment. Both the active pharmaceutical ingredients (APIs) and some excipients were detected in all analyzed tablets. Principal component analysis was used to analyze mass spectral features from different tablets showing strong clustering between tablets with different APIs. The obtained results suggest nano-DESI MS as future tool for forensic analysis to discern APIs present in unknown tablet samples.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmaceutiska ve ...

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