Sökning: WFRF:(Lindgren Katarina) > Pathogenic Ischemic...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07808naa a2201033 4500 | |
001 | oai:gup.ub.gu.se/206478 | |
003 | SwePub | |
008 | 240528s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:d884cda1-a1e2-47c7-9d09-799495f11feb | |
024 | 7 | a https://gup.ub.gu.se/publication/2064782 URI |
024 | 7 | a https://doi.org/10.1161/STROKEAHA.114.0073622 DOI |
024 | 7 | a https://lup.lub.lu.se/record/48200812 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ay, Hakan4 aut |
245 | 1 0 | a Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network |
264 | 1 | c 2014 |
520 | a BACKGROUND AND PURPOSE: NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium. METHODS: Fifty-two trained and certified adjudicators determined both phenotypic (abnormal test findings categorized in major pathogenic groups without weighting toward the most likely cause) and causative ischemic stroke subtypes in 16954 subjects with imaging-confirmed ischemic stroke from 12 US studies and 11 studies from 8 European countries using the web-based Causative Classification of Stroke System. Classification reliability was assessed with blinded readjudication of 1509 randomly selected cases. RESULTS: The distribution of pathogenic categories varied by study, age, sex, and race (P<0.001 for each). Overall, only 40% to 54% of cases with a given major ischemic stroke pathogenesis (phenotypic subtype) were classified into the same final causative category with high confidence. There was good agreement for both causative (κ 0.72; 95% confidence interval, 0.69-0.75) and phenotypic classifications (κ 0.73; 95% confidence interval, 0.70-0.75). CONCLUSIONS: This study demonstrates that pathogenic subtypes can be determined with good reliability in studies that include investigators with different expertise and background, institutions with different stroke evaluation protocols and geographic location, and patient populations with different epidemiological characteristics. The discordance between phenotypic and causative stroke subtypes highlights the fact that the presence of an abnormality in a patient with stroke does not necessarily mean that it is the cause of stroke. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a classification | |
653 | a pathogenesis | |
653 | a phenotype | |
700 | 1 | a Arsava, Ethem Murat4 aut |
700 | 1 | a Andsberg, Gunnaru Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-gan |
700 | 1 | a Benner, Thomas4 aut |
700 | 1 | a Brown Jr, Robert D.4 aut |
700 | 1 | a Chapman, Sherita N.4 aut |
700 | 1 | a Cole, John W.4 aut |
700 | 1 | a Delavaran, Hosseinu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hmh |
700 | 1 | a Dichgans, Martin4 aut |
700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen |
700 | 1 | a Giralt-Steinhauer, Eva4 aut |
700 | 1 | a Grewal, Raji P.4 aut |
700 | 1 | a Gwinn, Katrina4 aut |
700 | 1 | a Jern, Christina,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics4 aut0 (Swepub:gu)xjerch |
700 | 1 | a Jimenez-Conde, Jordi4 aut |
700 | 1 | a Jood, Katarina,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation4 aut0 (Swepub:gu)xjooka |
700 | 1 | a Katsnelson, Michael4 aut |
700 | 1 | a Kissela, Brett4 aut |
700 | 1 | a Kittner, Steven J.4 aut |
700 | 1 | a Kleindorfer, Dawn O.4 aut |
700 | 1 | a Labovitz, Daniel L.4 aut |
700 | 1 | a Lanfranconi, Silvia4 aut |
700 | 1 | a Lee, Jin-Moo4 aut |
700 | 1 | a Lehm, Manuel4 aut |
700 | 1 | a Lemmens, Robin4 aut |
700 | 1 | a Levi, Chris4 aut |
700 | 1 | a Li, Linxin4 aut |
700 | 1 | a Lindgren, Arneu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-ali |
700 | 1 | a Markus, Hugh S.4 aut |
700 | 1 | a McArdle, Patrick F.4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Norrving, Bou Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-bno |
700 | 1 | a Peddareddygari, Leema Reddy4 aut |
700 | 1 | a Pedersen, Annie,d 1981u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics4 aut0 (Swepub:gu)xpeder |
700 | 1 | a Pera, Joanna4 aut |
700 | 1 | a Rannikmäe, Kristiina4 aut |
700 | 1 | a Rexrode, Kathryn M.4 aut |
700 | 1 | a Rhodes, David4 aut |
700 | 1 | a Rich, Stephen S.4 aut |
700 | 1 | a Roquer, Jaume4 aut |
700 | 1 | a Rosand, Jonathan4 aut |
700 | 1 | a Rothwell, Peter M.4 aut |
700 | 1 | a Rundek, Tatjana4 aut |
700 | 1 | a Sacco, Ralph L.4 aut |
700 | 1 | a Schmidt, Reinhold4 aut |
700 | 1 | a Schürks, Markus4 aut |
700 | 1 | a Seiler, Stephan4 aut |
700 | 1 | a Sharma, Pankaj4 aut |
700 | 1 | a Slowik, Agnieszka4 aut |
700 | 1 | a Sudlow, Cathie4 aut |
700 | 1 | a Thijs, Vincent4 aut |
700 | 1 | a Woodfield, Rebecca4 aut |
700 | 1 | a Worrall, Bradford B.4 aut |
700 | 1 | a Meschia, James F.4 aut |
710 | 2 | a Neurologi, Lundb Sektion IV4 org |
773 | 0 | t Strokeg 45:12, s. 3589-3596q 45:12<3589-96x 0039-2499 |
773 | 0 | t Stroke: a journal of cerebral circulationg 45:12, s. 3589-3596q 45:12<3589-3596x 1524-4628 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25378430?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1161/STROKEAHA.114.007362y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/206478 |
856 | 4 8 | u https://doi.org/10.1161/STROKEAHA.114.007362 |
856 | 4 8 | u https://lup.lub.lu.se/record/4820081 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy