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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004005naa a2200409 4500
001oai:DiVA.org:uu-171161
003SwePub
008120315s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1711612 URI
0247 a https://doi.org/10.1371/journal.pone.00065542 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Røe, Oluf Dimitri4 aut
2451 0a Genome-wide profile of pleural mesothelioma versus parietal and visceral pleura :b the emerging gene portrait of the mesothelioma phenotype
264 c 2009-08-07
264 1b Public Library of Science (PLoS),c 2009
338 a print2 rdacarrier
520 a BACKGROUND: Malignant pleural mesothelioma is considered an almost incurable tumour with increasing incidence worldwide. It usually develops in the parietal pleura, from mesothelial lining or submesothelial cells, subsequently invading the visceral pleura. Chromosomal and genomic aberrations of mesothelioma are diverse and heterogenous. Genome-wide profiling of mesothelioma versus parietal and visceral normal pleural tissue could thus reveal novel genes and pathways explaining its aggressive phenotype. METHODOLOGY AND PRINCIPAL FINDINGS: Well-characterised tissue from five mesothelioma patients and normal parietal and visceral pleural samples from six non-cancer patients were profiled by Affymetrix oligoarray of 38 500 genes. The lists of differentially expressed genes tested for overrepresentation in KEGG PATHWAYS (Kyoto Encyclopedia of Genes and Genomes) and GO (gene ontology) terms revealed large differences of expression between visceral and parietal pleura, and both tissues differed from mesothelioma. Cell growth and intrinsic resistance in tumour versus parietal pleura was reflected in highly overexpressed cell cycle, mitosis, replication, DNA repair and anti-apoptosis genes. Several genes of the "salvage pathway" that recycle nucleobases were overexpressed, among them TYMS, encoding thymidylate synthase, the main target of the antifolate drug pemetrexed that is active in mesothelioma. Circadian rhythm genes were expressed in favour of tumour growth. The local invasive, non-metastatic phenotype of mesothelioma, could partly be due to overexpression of the known metastasis suppressors NME1 and NME2. Down-regulation of several tumour suppressor genes could contribute to mesothelioma progression. Genes involved in cell communication were down-regulated, indicating that mesothelioma may shield itself from the immune system. Similarly, in non-cancer parietal versus visceral pleura signal transduction, soluble transporter and adhesion genes were down-regulated. This could represent a genetical platform of the parietal pleura propensity to develop mesothelioma. CONCLUSIONS: Genome-wide microarray approach using complex human tissue samples revealed novel expression patterns, reflecting some important features of mesothelioma biology that should be further explored.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Pathology
653 a Patologi
7001 a Anderssen, Endre4 aut
7001 a Helge, Eli4 aut
7001 a Pettersen, Caroline Hild4 aut
7001 a Olsen, Karina Standahl4 aut
7001 a Sandeck, Helmut4 aut
7001 a Haaverstad, Rune4 aut
7001 a Lundgren, Steinar4 aut
7001 a Larsson, Erik4 aut
7730 t PLOS ONEd : Public Library of Science (PLoS)g 4:8, s. e6554-q 4:8<e6554-x 1932-6203
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006554&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171161
8564 8u https://doi.org/10.1371/journal.pone.0006554

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