Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays.

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Fältnamn	Indikatorer	Metadata
000		04757naa a2200697 4500
001		oai:gup.ub.gu.se/53355
003		SwePub
008		240528s2006 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:9535b78f-ec83-4f94-b4d6-d9d0a1311d93
024	7	a https://gup.ub.gu.se/publication/533552 URI
024	7	a https://doi.org/10.1074/mcp.M600170-MCP2002 DOI
024	7	a https://lup.lub.lu.se/record/3929852 URI
040		a (SwePub)gud (SwePub)lu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ellmark, Peteru Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-pel
245	1 0	a Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays.
264	1	c 2006
520		a Antibody microarray based technology is a powerful emerging tool in proteomics, target discovery, and differential analysis. Here, we report the first study where recombinant antibody fragments have been used to construct large scale antibody microarrays, composed of 127 different antibodies against mostly immunoregulatory antigens. The arrays were based on single framework recombinant antibody fragments (SinFabs) designed for high on-chip stability and functionality and were used for the analysis of malignant and normal stomach tissue samples from Helicobacter pylori-positive and -negative patients. Our results demonstrate that distinct tumor- as well as infection-associated protein expression signatures could be identified from these complex tissue proteomes, as well as biomarkers such as IL-9, IL-11, and MCP-4, previously not found in these diseases. In a longer perspective, this study may improve the understanding of H. pylori-induced stomach cancer and lead to development of improved diagnostics.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653		a Adenocarcinoma
653		a immunology
653		a metabolism
653		a microbiology
653		a Aged
653		a Aged
653		a 80 and over
653		a Antibodies
653		a chemistry
653		a Female
653		a Helicobacter Infections
653		a immunology
653		a metabolism
653		a microbiology
653		a Helicobacter pylori
653		a Humans
653		a Male
653		a Middle Aged
653		a Protein Array Analysis
653		a Proteomics
653		a Recombinant Proteins
653		a immunology
653		a metabolism
653		a Stomach Neoplasms
653		a immunology
653		a metabolism
653		a microbiology
700	1	a Ingvarsson, Johanu Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-jin
700	1	a Carlsson, Andersu Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immu-aca
700	1	a Lundin, Samuel B,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xlusam
700	1	a Wingren, Christeru Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-cwi
700	1	a Borrebaeck, Carlu Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-cbo
710	2	a Institutionen för immunteknologib Institutioner vid LTH4 org
773	0	t Molecular & cellular proteomics : MCPg 5:9, s. 1638-46q 5:9<1638-46x 1535-9476x 1535-9484
856	4	u http://dx.doi.org/10.1074/mcp.M600170-MCP200y FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/53355
856	4 8	u https://doi.org/10.1074/mcp.M600170-MCP200
856	4 8	u https://lup.lub.lu.se/record/392985

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Molecular & cellular proteomics : MCP (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Ellmark, Peter; Ingvarsson, Joha ...; Carlsson, Anders; Lundin, Samuel B ...; Wingren, Christe ...; Borrebaeck, Carl

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Immunologi inom ...

Artiklar i publikationen: Molecular & cell ...

Av lärosätet: Göteborgs universitet; Lunds universitet

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