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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007824naa a2200949 4500
001oai:gup.ub.gu.se/296937
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:d0cf0da8-5c1b-4b21-8f21-2de7375274ed
0247 a https://gup.ub.gu.se/publication/2969372 URI
0247 a https://doi.org/10.1136/bmjopen-2019-0347772 DOI
0247 a https://lup.lub.lu.se/record/d0cf0da8-5c1b-4b21-8f21-2de7375274ed2 URI
040 a (SwePub)gud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Yeap, B. B.u University of Western Australia, Crawley4 aut
2451 0a Androgens in men study (AIMS): Protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men
264 c 2020-05-11
264 1b BMJ,c 2020
520 a Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality risk, and to identify factors predicting testosterone concentrations. Data will be accrued from at least three Australian, two European and four North American population-based cohorts involving approximately 20 000 men. Methods and analysis Eligible studies include prospective cohort studies with baseline testosterone concentrations measured using mass spectrometry and 5 years of follow-up data on incident cardiovascular events, mortality, cancer diagnoses or deaths, new-onset dementia or decline in cognitive function recorded. Data for men, who were not taking androgens or drugs suppressing testosterone production, metabolism or action; and had no prior orchidectomy, are eligible. Systematic literature searches were conducted from 14 June 2019 to 31 December 2019, with no date range set for searches. Aggregate level data will be sought where individual participant data (IPD) are not available. One-stage IPD random-effects meta-analyses will be performed, using linear mixed models, generalised linear mixed models and either stratified or frailty-augmented Cox regression models. Heterogeneity in estimates from different studies will be quantified and bias investigated using funnel plots. Effect size estimates will be presented in forest plots and non-negligible heterogeneity and bias investigated using subgroup or meta-regression analyses. Ethics and dissemination Ethics approvals obtained for each of the participating cohorts state that participants have consented to have their data collected and used for research purposes. The Androgens In Men Study has been assessed as exempt from ethics review by the Human Ethics office at the University of Western Australia (file reference number RA/4/20/5014). Each of the component studies had obtained ethics approvals; please refer to respective component studies for details. Research findings will be disseminated to the scientific and broader community via the publication of four research articles, with each involving a separate set of IPD meta-analyses (articles will investigate different, distinct outcomes), at scientific conferences and meetings of relevant professional societies. Collaborating cohort studies will disseminate findings to study participants and local communities. PROSPERO registration number CRD42019139668. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a epidemiology
653 a general endocrinology
653 a sex steroids & HRT
653 a androgen
653 a androstanolone
653 a estradiol
653 a luteinizing hormone
653 a sex hormone binding globulin
653 a testosterone
653 a Article
653 a clinical outcome
653 a clinical protocol
653 a cognitive defect
653 a dementia
653 a disease association
653 a follow up
653 a frailty
653 a human
653 a malignant neoplasm
653 a mass spectrometry
653 a men's health
653 a meta analysis
653 a reference value
653 a systematic review
653 a testosterone metabolism
653 a testosterone synthesis
7001 a Marriott, R. J.u University of Western Australia, Crawley4 aut
7001 a Adams, R. J.u Flinders University4 aut
7001 a Antonio, L.u Catholic University of Leuven4 aut
7001 a Ballantyne, C. M.u Baylor College of Medicine4 aut
7001 a Bhasin, S.u Harvard Medical School4 aut
7001 a Cawthon, P. M.u California Pacific Medical Center4 aut
7001 a Couper, D. J.u University of North Carolina4 aut
7001 a Dobs, A. S.u Johns Hopkins University4 aut
7001 a Flicker, L.u University of Western Australia, Crawley4 aut
7001 a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka
7001 a Martin, S. A.u University of Adelaide4 aut
7001 a Matsumoto, A. M.u VA Puget Sound Health Care System,Washington University School of Medicine4 aut
7001 a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy4 aut0 (Swepub:gu)xmelda
7001 a Norman, P. E.u University of Western Australia, Crawley4 aut
7001 a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy4 aut0 (Swepub:gu)xohlcl
7001 a Orwoll, E. S.u Oregon Health & Science University4 aut
7001 a O'Neill, T. W.u University of Manchester,Manchester University NHS Foundation Trust4 aut
7001 a Shores, M. M.u Washington University School of Medicine,VA Puget Sound Health Care System4 aut
7001 a Travison, T. G.u Beth Israel Deaconess Medical Center,Harvard Medical School4 aut
7001 a Vanderschueren, D.u Catholic University of Leuven4 aut
7001 a Wittert, G. A.u University of Adelaide4 aut
7001 a Wu, F. C. W.u University of Manchester4 aut
7001 a Murray, K.u University of Western Australia, Crawley4 aut
7102 a University of Western Australia, Crawleyb Flinders University4 org
7730 t BMJ Opend : BMJg 10:5q 10:5x 2044-6055
8564 u https://bmjopen.bmj.com/content/bmjopen/10/5/e034777.full.pdf
8564 u http://dx.doi.org/10.1136/bmjopen-2019-034777x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/296937
8564 8u https://doi.org/10.1136/bmjopen-2019-034777
8564 8u https://lup.lub.lu.se/record/d0cf0da8-5c1b-4b21-8f21-2de7375274ed

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