Randomized evaluation of routine beta-blocker therapy after myocardial infarction quality of life (RQoL): design and rationale of a multicentre, prospective, randomized, open, blinded endpoint study

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Fältnamn	Indikatorer	Metadata
000		04406naa a2200385 4500
001		oai:DiVA.org:uu-508389
003		SwePub
008		230731s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:237265820
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5083892 URI
024	7	a https://doi.org/10.1093/ehjopen/oead0362 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2372658202 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Humphries, Sophiau Karolinska Institutet,Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, 23100, Karolinska Institute , 141 83 Huddinge , Sweden4 aut0 (Swepub:uu)sophu436
245	1 0	a Randomized evaluation of routine beta-blocker therapy after myocardial infarction quality of life (RQoL) :b design and rationale of a multicentre, prospective, randomized, open, blinded endpoint study
264	1	b Oxford University Press,c 2023
338		a electronic2 rdacarrier
520		a AimsMost cases of acute myocardial infarction (MI) in Sweden are treated with long-term β-blocker therapy as secondary prevention. Case studies and patient reports have indicated negative effects of β-blockers including symptoms of depression, fatigue, sexual dysfunction, and general low mood, all related to reduced quality of life (QoL). To date, no recent large-scale, randomized trial has explored the effects of β-blockers on these factors.Methods and resultsThe ongoing Randomized Evaluation of Decreased Usage of beta-bloCkErs after myocardial infarction (REDUCE): quality of life (RQoL) study is a multicentre, prospective, randomized pre-specified substudy aiming to evaluate the effects of β-blockers on self-reported measures of QoL. Following randomized allocation to long-term β-blocker or no β-blocker treatment, patients complete a total of six baseline measures pertaining to QoL, sexual functioning, and perceived side effects. Data collection is optionally carried out online through a unique and secure portal and repeated again at two follow-up time points. Recruitment began in July 2018. Data from the first 100 patients showed that at the first follow-up, 93% had completed the questionnaires, which decreased to 81% at the second follow-up. The method of digital data collection was utilized by over half of the patients recruited so far.ConclusionData from the first 100 patients indicate success in terms of study design and recruitment. The RQoL substudy investigates the effects of β-blockers on self-reported measures of QoL in MI patients and will potentially contribute to the limited knowledge of QoL-related side effects reported in conjunction with β-blocker use.Clinical trial registrationEudra CT number, 2017-002336-17; Clinical trial.gov identifier, NCT03278509
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Mars, Katarinau Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institute , Stockholm , Sweden4 aut
700	1	a Hofmann, Robinu Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institute , Stockholm , Sweden4 aut
700	1	a Held, Claes,d 1956-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)clahe947
700	1	a Olsson, Erik,d 1967-u Uppsala universitet,Hälsovetenskap och e-hälsa4 aut0 (Swepub:uu)erols031
710	2	a Karolinska Institutetb Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, 23100, Karolinska Institute , 141 83 Huddinge , Sweden4 org
773	0	t European Heart Journal Opend : Oxford University Pressg 3:3q 3:3x 2752-4191
856	4	u https://doi.org/10.1093/ehjopen/oead036y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1784796/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508389
856	4 8	u https://doi.org/10.1093/ehjopen/oead036
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:237265820

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Av författaren/redakt...: Humphries, Sophi ...; Mars, Katarina; Hofmann, Robin; Held, Claes, 195 ...; Olsson, Erik, 19 ...

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