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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004808naa a2200505 4500
001oai:DiVA.org:uu-299894
003SwePub
008160729s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2998942 URI
0247 a https://doi.org/10.1186/s12974-016-0624-52 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mazzeo, Anna Teresau Univ Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.4 aut
2451 0a Multivariate projection method to investigate inflammation associated with secondary insults and outcome after human traumatic brain injury :b a pilot study
264 c 2016-06-21
264 1b Springer Science and Business Media LLC,c 2016
338 a electronic2 rdacarrier
520 a Background: Neuroinflammation has been proposed as a possible mechanism of brain damage after traumatic brain injury (TBI), but no consensus has been reached on the most relevant molecules. Furthermore, secondary insults occurring after TBI contribute to worsen neurological outcome in addition to the primary injury. We hypothesized that after TBI, a specific pattern of cytokines is related to secondary insults and outcome. Methods: A prospective observational clinical study was performed. Secondary insults by computerized multimodality monitoring system and systemic value of different cytokines were collected and analysed in the first week after intensive care unit admission. Neurological outcome was assessed at 6 months (GOSe). Multivariate projection technique was applied to analyse major sources of variation and collinearity within the cytokines dataset without a priori selecting potential relevant molecules. Results: Twenty-nine severe traumatic brain injury patients undergoing intracranial pressure monitoring were studied. In this pilot study, we demonstrated that after TBI, patients who suffered of prolonged and severe secondary brain damage are characterised by a specific pattern of cytokines. Patients evolving to brain death exhibited higher levels of inflammatory mediators compared to both patients with favorable and unfavorable neurological outcome at 6 months. Raised ICP and low cerebral perfusion pressure occurred in 21 % of good monitoring time. Furthermore, the principal components selected by multivariate projection technique were powerful predictors of neurological outcome. Conclusions: The multivariate projection method represents a valuable methodology to study neuroinflammation pattern occurring after secondary brain damage in severe TBI patients, overcoming multiple putative interactions between mediators and avoiding any subjective selection of relevant molecules.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Traumatic brain injury
653 a Intracranial hypertension
653 a Secondary insults
653 a Neuroinflammation
653 a Cytokines
653 a Principal component analysis
7001 a Filippini, Claudiau Univ Turin, Dept Surg Sci, Turin, Italy.4 aut
7001 a Rosato, Rosalbau Univ Turin, Dept Psychol, Turin, Italy.4 aut
7001 a Fanelli, Vitou Univ Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.4 aut
7001 a Assenzio, Barbarau Univ Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.4 aut
7001 a Piper, Ianu So Gen Hosp, Dept Clin Phys, Glasgow, Lanark, Scotland.4 aut
7001 a Howells, Timothyu Uppsala universitet,Neurokirurgi4 aut0 (Swepub:uu)timho266
7001 a Mastromauro, Ilariau Univ Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.4 aut
7001 a Berardino, Mauriziou AOU Citta Salute & Sci Torino, Presidio CTO, Anesthesia & Intens Care Unit, Turin, Italy.4 aut
7001 a Ducati, Alessandrou Univ Turin, Dept Neurosci, Neurosurg Unit, Turin, Italy.4 aut
7001 a Mascia, Lucianau Univ Roma La Sapienza, Dipartimento Sci & Biotecnol Med Chirurg, Rome, Italy.4 aut
7102 a Univ Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.b Univ Turin, Dept Surg Sci, Turin, Italy.4 org
7730 t Journal of Neuroinflammationd : Springer Science and Business Media LLCg 13q 13x 1742-2094
8564 u https://uu.diva-portal.org/smash/get/diva2:950383/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/s12974-016-0624-5
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299894
8564 8u https://doi.org/10.1186/s12974-016-0624-5

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