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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003933naa a2200553 4500
001oai:DiVA.org:kth-23909
003SwePub
008100810s2004 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1935168
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-239092 URI
0247 a https://doi.org/10.1111/j.0742-2822.2004.03164.x2 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19351682 URI
040 a (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Quintana, M.u Karolinska Institutet4 aut
2451 0a Electromechanical coupling, uncoupling, and ventricular function in patients with bundle branch block :b A tissue-doppler echocardiographic study
264 c 2009-09-25
264 1b Wiley,c 2004
338 a print2 rdacarrier
500 a QC 20100525 QC 20120221
520 a Background: Left bundle branch block (LBBB) is associated with impaired left ventricular (LV) function and increased morbidity and mortality, especially in patients with structural heart diseases. The mechanisms are poorly understood. Subjects and Methods: Subjects with isolated LBBB (n = 20), right bundle branch block (RBBB, n = 20), and controls (C, n = 20) were studied with standard two-dimentional (2D), and color-encoded tissue-Doppler echocardiography (TDE). Inter- and intraventricular systolic and diastolic coordination were assessed from the TDE velocity profiles. LV function was assessed by 2D echocardiography, by TDE-derived peak systolic velocities, and the atrioventricular (AV) plane displacement. Results: Subjects with LBBB had longer electromechanical delays and longer isovolumic relaxation times than did the C and RBBB groups (P < 0.001). For the LBBB subjects compared with the RBBB and C groups, ejection times were shorter, peak systolic velocities and AV plane displacements were lower, they had larger LV end-systolic volumes and lower LV ejection fraction (all P < 0.001), and the atrial contribution to A-V plane displacement was higher (P < 0.01). There were no differences in diastolic or filling times among the groups. Conclusions: In patients with LBBB, delayed regional electromechanical coupling and uncoupling leads to generalized intra- and interventricular asynchrony, thereby explaining the depressed regional and global LV functions. Assessment of the electromechanical coupling and uncoupling processes and their consequences on cardiac function in patients with BBB and structural heart diseases may be possible using TDE.
653 a bundle branch block
653 a tissue-Doppler echocardiography
653 a left ventricular function
653 a coronary-artery disease
653 a intraventricular-conduction delay
653 a chronic heart-failure
653 a dilated cardiomyopathy
653 a cardiac resynchronization
653 a myocardial-infarction
653 a abnormal activation
653 a general-population
653 a natural-history
653 a mortality
7001 a Saha, S.u Karolinska Institutet4 aut
7001 a Rohani, M.4 aut
7001 a del Furia, F.4 aut
7001 a Roumina, S.4 aut
7001 a Lind, Brittau Department of Clinical Physiology, Huddinge University Hospital4 aut0 (Swepub:kth)u1sy2e01
7001 a Hayashi, S.4 aut
7001 a Brodin, Lars-Åkeu Karolinska Institutet4 aut0 (Swepub:kth)u1jq9s27
7102 a Karolinska Institutetb Department of Clinical Physiology, Huddinge University Hospital4 org
7730 t Echocardiographyd : Wileyg 21:8, s. 687-698q 21:8<687-698x 0742-2822x 1540-8175
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-23909
8564 8u https://doi.org/10.1111/j.0742-2822.2004.03164.x
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1935168

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