SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Roman S)
 

Sökning: WFRF:(Roman S) > (2005-2009) > Postnatal constrict...

Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus

Levin, Max, 1969 (författare)
Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
McCurnin, D. (författare)
Seidner, S. R. (författare)
visa fler...
Yoder, B. (författare)
Waleh, N. (författare)
Goldbarg, S. (författare)
Roman, C. (författare)
Liu, B. M. (författare)
Borén, Jan, 1963 (författare)
Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
Clyman, R. I. (författare)
visa färre...
 (creator_code:org_t)
American Physiological Society, 2006
2006
Engelska.
Ingår i: Am J Physiol Regul Integr Comp Physiol. - : American Physiological Society. - 0363-6119. ; 290:2
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • After birth, constriction of the full-term ductus arteriosus induces oxygen, glucose and ATP depletion, cell death, and anatomic remodeling of the ductus wall. The immature ductus frequently fails to develop the same degree of constriction or anatomic remodeling after birth. In addition, the immature ductus loses its ability to respond to vasoconstrictive agents, like oxygen or indomethacin, with increasing postnatal age. We examined the effects of premature delivery and postnatal constriction on the immature baboon ductus arteriosus. By 6 days after birth, surrogate markers of hypoxia (HIF1alpha/VEGF mRNA) and cell death [dUTP nick-end labeling (TUNEL)-staining] increased, while glucose and ATP concentrations (bioluminescence imaging) decreased in the immature ductus. TUNEL-staining was significantly related to the degree of glucose and ATP depletion. Glucose and ATP depletion were directly related to the degree of ductus constriction; while TUNEL-staining was logarithmically related to the degree of ductus constriction. Extensive cell death (>15% TUNEL-positive cells) occurred only when there was no Doppler flow through the ductus lumen. In contrast, HIF1alpha/VEGF expression and ATP concentrations were significantly altered even when the immature ductus remained open after birth. Decreased ATP concentrations produced decreased oxygen-induced contractile responses in the immature ductus. We hypothesize that ATP depletion in the persistently patent immature newborn ductus is insufficient to induce cell death and remodeling but sufficient to decrease its ability to constrict after birth. This may explain its decreasing contractile response to oxygen, indomethacin, and other contractile agents with increasing postnatal age.

Nyckelord

Adenosine Triphosphate/*metabolism
Animals
Animals
Newborn
Anoxia
Cell Death
Ductus Arteriosus/*metabolism/*pathology/physiology/physiopathology
Gene Expression Regulation
Glucose/metabolism
Glycogen/metabolism
Hypoxia-Inducible Factor 1
alpha Subunit/metabolism
Papio
Sheep
Vascular Endothelial Growth Factor A/metabolism

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy