Effectiveness of Written Dietary Advice for Improving Blood Lipids in Primary Care Adults-A Pragmatic Randomized Controlled Trial (MYDICLIN)

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Fältnamn	Indikatorer	Metadata
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001		oai:DiVA.org:uu-470551
003		SwePub
008		220328s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:149051553
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4705512 URI
024	7	a https://doi.org/10.3390/nu140510222 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1490515532 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Rydell, Andreasu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning Dalarna,Norslund Svardsjo Acad Primary Hlth Care Ctr, Svardsjo Vardcentral Bjorkvagen 2, S-79023 Svardsjo, Sweden.;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Alfred Nobels 23, S-14183 Huddinge, Sweden.4 aut
245	1 0	a Effectiveness of Written Dietary Advice for Improving Blood Lipids in Primary Care Adults-A Pragmatic Randomized Controlled Trial (MYDICLIN)
264		c 2022-02-28
264	1	b MDPI AG,c 2022
338		a electronic2 rdacarrier
520		a Lifestyle management is the first line of treatment for moderately elevated blood lipids in healthy individuals. We investigated the effectiveness of providing food-based written advice for lowering low-density lipoprotein (LDL) cholesterol (intervention) or triglycerides (control) in a pragmatic randomized controlled trial with two parallel arms from 2018-2019 at a rural primary health care center. We sent feedback letters after 3 weeks and 6 months. Out of the 113 adult primary care patients randomized, 112 completed the study. There were no differences between the intervention and control groups for changes in LDL cholesterol after 3 weeks (mean +/- standard deviation -0.21 +/- 0.38 vs. -0.11 +/- 0.34 mmol/L, p = 0.45) or 6 months (-0.05 +/- 0.47 vs. 0.02 +/- 0.41 mmol/L, p = 0.70) (primary outcome). Following the advice to consume plant sterols and turmeric was associated with a reduction in LDL cholesterol after 3 weeks. Following the advice to consume less carbohydrates was associated with reduced triglycerides. In the intervention arm, 14 individuals (25%) reduced their LDL cholesterol by >= 10% after three weeks. Their reduction was attenuated but maintained after six months (-7.1 +/- 9.2% or -0.31 +/- 0.38 mmol/L, p = 0.01 compared with baseline). They differed only in higher adherence to the advice regarding turmeric. In conclusion, this undemanding intervention had little effect on blood lipids for most individuals.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653		a LDL cholesterol
653		a triglycerides
653		a lipids
653		a primary care
653		a foods
653		a dietary advice
700	1	a Hellsten, Mikaelu Norslund Svardsjo Acad Primary Hlth Care Ctr, Svardsjo Vardcentral Bjorkvagen 2, S-79023 Svardsjo, Sweden.4 aut
700	1	a Lindow, Martinu Örebro Univ, Sch Med Sci, Campus USO, S-70182 Örebro, Sweden.4 aut
700	1	a Iggman, Davidu Uppsala universitet,Klinisk nutrition och metabolism,Centrum för klinisk forskning Dalarna,Norslund Svardsjo Acad Primary Hlth Care Ctr, Svardsjo Vardcentral Bjorkvagen 2, S-79023 Svardsjo, Sweden.4 aut0 (Swepub:uu)davig338
710	2	a Uppsala universitetb Centrum för klinisk forskning Dalarna4 org
773	0	t Nutrientsd : MDPI AGg 14:5q 14:5x 2072-6643
856	4	u https://doi.org/10.3390/nu14051022y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1647659/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.mdpi.com/2072-6643/14/5/1022/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470551
856	4 8	u https://doi.org/10.3390/nu14051022
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:149051553

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Av författaren/redakt...: Rydell, Andreas; Hellsten, Mikael; Lindow, Martin; Iggman, David

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