Origins of spousal cross-concordance for psychiatric disorders : A test of the social stress theory for alcohol use disorder

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Fältnamn	Indikatorer	Metadata
000		04194naa a2200433 4500
001		oai:lup.lub.lu.se:84d43811-a8a0-492c-990b-64db4f3fd91b
003		SwePub
008		230828s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/84d43811-a8a0-492c-990b-64db4f3fd91b2 URI
024	7	a https://doi.org/10.1017/S00332917220017382 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Salvatore, Jessica E.u Virginia Commonwealth University4 aut
245	1 0	a Origins of spousal cross-concordance for psychiatric disorders : A test of the social stress theory for alcohol use disorder
264	1	c 2023
520		a Background The authors sought to clarify the impact of spousal psychiatric disorders of differing severity [major depression or anxiety disorders (DAD) v. bipolar disorder or nonaffective psychosis (BPN)] on proband risk for alcohol use disorder (AUD) during marriage. Methods In a Swedish cohort (N = 744 628), associations between spousal DAD and BPN and proband AUD were estimated with Cox proportional hazards; associations between parental AUD, proband premarital AUD, and spousal lifetime DAD and BPN were estimated with logistic regression; and whether spousal DAD or BPN causally increased risk for AUD was evaluated with frailty models. Results Spousal premarital DAD, spousal marital-onset DAD, and spousal BPN (premarital or marital-onset) were associated with proband AUD during marriage [hazard ratios (HR) range 1.44-3.72]. Those with a parental or premarital history of AUD (v. without) were more likely to marry a spouse with DAD or BPN (odds ratios 1.22-2.77). Moving from an unaffected first spouse to a DAD-affected second spouse increased AUD risk in males (HR 2.90). Moving from an unaffected first spouse to a BPN-affected second spouse increased AUD risk (HRmales 3.96; HRfemales 5.64). Moving to an unaffected second spouse from a DAD-affected first spouse decreased AUD risk, with stronger evidence in females compared to males (HRmales 0.59; HRfemales 0.28). Conclusions Associations between spousal DAD or BPN and proband AUD reflect both selection and causal effects. Marriage to a BPN-affected spouse has a particularly strong effect on AUD risk, with more modest effects for spousal DAD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Beroendelära0 (SwePub)303092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Substance Abuse0 (SwePub)303092 hsv//eng
653		a Alcohol use disorder
653		a anxiety disorders
653		a bipolar disorder
653		a major depression
653		a nonaffective psychosis
653		a social stress
653		a spousal influences
700	1	a Larsson Lönn, Sarau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)mats-sla
700	1	a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-jsu
700	1	a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ksq
700	1	a Kendler, Kenneth S.u Virginia Commonwealth University4 aut
710	2	a Virginia Commonwealth Universityb Allmänmedicin och klinisk epidemiologi4 org
773	0	t Psychological Medicineg 53:10, s. 4772-4779q 53:10<4772-4779x 0033-2917
856	4	u http://dx.doi.org/10.1017/S0033291722001738y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/84d43811-a8a0-492c-990b-64db4f3fd91b
856	4 8	u https://doi.org/10.1017/S0033291722001738

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Av författaren/redakt...: Salvatore, Jessi ...; Larsson Lönn, Sa ...; Sundquist, Jan; Sundquist, Krist ...; Kendler, Kenneth ...

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