A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

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Fältnamn	Indikatorer	Metadata
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001		oai:DiVA.org:uu-451570
003		SwePub
008		210916s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:147028274
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4515702 URI
024	7	a https://doi.org/10.1038/s41467-021-23899-y2 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1470282742 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Jhun, Mina-Au Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.4 aut
245	1 0	a A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
264		c 2021-06-28
264	1	b Springer Nature,c 2021
338		a electronic2 rdacarrier
520		a Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups. Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Mendelson, Michaelu NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Boston Childrens Hosp, Dept Cardiol, Boston, MA USA.4 aut
700	1	a Wilson, Roryu German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.4 aut
700	1	a Gondalia, Rahulu Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA.4 aut
700	1	a Joehanes, Robyu Harvard Med Sch, Beth Israel Deaconess Med Ctr, Hebrew SeniorLife, Boston, MA 02115 USA.4 aut
700	1	a Salfati, Eliasu Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.4 aut
700	1	a Zhao, Xiaopingu Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, McGovern Med Sch, Houston, TX 77030 USA.4 aut
700	1	a Braun, Kim Valeska Emilieu Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700	1	a Do, Anh Nguyetu Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.4 aut
700	1	a Hedman, Åsa Ku Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ashed124
700	1	a Zhang, Taou Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.4 aut
700	1	a Carnero-Montoro, Elenau Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London, England.;Univ Granada, Ctr Genom & Oncol Res Pfizer, GENYO, Andalusian Reg Govt, Granada, Spain.4 aut
700	1	a Shen, Jinchengu Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.4 aut
700	1	a Bartz, Traci M.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Biostat, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.4 aut
700	1	a Brody, Jennifer A.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut
700	1	a Montasser, May E.u Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.4 aut
700	1	a O'Connell, Jeff R.u Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.4 aut
700	1	a Yao, Chenu NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.4 aut
700	1	a Xia, Ruiu Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, McGovern Med Sch, Houston, TX 77030 USA.4 aut
700	1	a Boerwinkle, Ericu Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.4 aut
700	1	a Grove, Meganu Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.4 aut
700	1	a Guan, Weihuau Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN USA.4 aut
700	1	a Liliane, Pfeifferu German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.4 aut
700	1	a Singmann, Paulau German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.4 aut
700	1	a Mueller-Nurasyid, Martinau German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, IBE, Fac Med, Munich, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.4 aut
700	1	a Meitinger, Thomasu Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.;German Res Ctr Environm Hlth, Inst Human Genet, Helmholtz Zentrum Munchen, Munich, Germany. Tech Univ Munich, Inst Human Genet, Munich, Germany.4 aut
700	1	a Gieger, Christianu German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.4 aut
700	1	a Peters, Annetteu German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.4 aut
700	1	a Zhao, Weiu Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.4 aut
700	1	a Ware, Erin B.u Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Survey Res Ctr, Inst Social Res, Ann Arbor, MI USA.4 aut
700	1	a Smith, Jennifer A.u Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Survey Res Ctr, Inst Social Res, Ann Arbor, MI USA.4 aut
700	1	a Dhana, Klodianu Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA.4 aut
700	1	a van Meurs, Joyceu Erasmus MC, Univ Med Ctr, Dept Internal Med, Rotterdam, Netherlands.4 aut
700	1	a Uitterlinden, Andreu Erasmus MC, Univ Med Ctr, Dept Internal Med, Rotterdam, Netherlands.4 aut
700	1	a Ikram, Mohammad Arfanu Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700	1	a Ghanbari, Mohsenu Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700	1	a Zhi, Deugiu Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Houston, TX 77030 USA.4 aut
700	1	a Gustafsson, Stefanu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi4 aut0 (Swepub:uu)stegu732
700	1	a Lind, Larsu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)larslind
700	1	a Li, Shengxuu Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.4 aut
700	1	a Sun, Dianjianyiu Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.;Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.4 aut
700	1	a Spector, Tim D.u Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London, England.4 aut
700	1	a Chen, Yii-der Idau Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA.4 aut
700	1	a Damcott, Coleenu Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.4 aut
700	1	a Shuldiner, Alan R.u Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.4 aut
700	1	a Absher, Devin M.u HudsonAlpha Inst Biotechnol, Huntsville, AL USA.4 aut
700	1	a Horvath, Steveu Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Dept Biostat, Fielding Sch Publ Hlth, Los Angeles, CA USA.4 aut
700	1	a Tsao, Philip S.u Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.;VA Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.4 aut
700	1	a Kardia, Sharonu Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.4 aut
700	1	a Psaty, Bruce M.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA.4 aut
700	1	a Sotoodehnia, Nonau Univ Washington, Div Cardiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.4 aut
700	1	a Bell, Jordana T.u Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London, England.4 aut
700	1	a Ingelsson, Erik,d 1975-u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.;UppStanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.4 aut0 (Swepub:uu)ering425
700	1	a Chen, Weiu Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.4 aut
700	1	a Dehghan, Abbasu Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.;Imperial Coll, Sch Publ Hlth, MRC Ctr Environm & Hlth, Dept Biostat & Epidemiol, London, England.4 aut
700	1	a Arnett, Donna K.u Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.4 aut
700	1	a Waldenberger, Melanieu German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.4 aut
700	1	a Hou, Lifangu Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.4 aut
700	1	a Whitsel, Eric A.u Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Med, Chapel Hill, NC 27515 USA.4 aut
700	1	a Baccarelli, Andreau Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth Sci, Boston, MA USA.;Columbia Univ, Dept Environm Hlth Sci, Mailman Sch Publ Hlth, New York, NY USA.4 aut
700	1	a Levy, Danielu NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA.4 aut
700	1	a Fornage, Myriamu Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, McGovern Med Sch, Houston, TX 77030 USA.4 aut
700	1	a Irvin, Marguerite R.u Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.4 aut
700	1	a Assimes, Themistocles L.u Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.;VA Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.4 aut
710	2	a Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.b NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Boston Childrens Hosp, Dept Cardiol, Boston, MA USA.4 org
773	0	t Nature Communicationsd : Springer Natureg 12:1q 12:1x 2041-1723
856	4	u https://doi.org/10.1038/s41467-021-23899-yy Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1594816/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.nature.com/articles/s41467-021-23899-y.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-451570
856	4 8	u https://doi.org/10.1038/s41467-021-23899-y
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:147028274

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Av författaren/redakt...: Jhun, Mina-A; Mendelson, Micha ...; Wilson, Rory; Gondalia, Rahul; Joehanes, Roby; Salfati, Elias; visa fler...; Zhao, Xiaoping; Braun, Kim Vales ...; Do, Anh Nguyet; Hedman, Åsa K; Zhang, Tao; Carnero-Montoro, ...; Shen, Jincheng; Bartz, Traci M.; Brody, Jennifer ...; Montasser, May E ...; O'Connell, Jeff ...; Yao, Chen; Xia, Rui; Boerwinkle, Eric; Grove, Megan; Guan, Weihua; Liliane, Pfeiffe ...; Singmann, Paula; Mueller-Nurasyid ...; Meitinger, Thoma ...; Gieger, Christia ...; Peters, Annette; Zhao, Wei; Ware, Erin B.; Smith, Jennifer ...; Dhana, Klodian; van Meurs, Joyce; Uitterlinden, An ...; Ikram, Mohammad ...; Ghanbari, Mohsen; Zhi, Deugi; Gustafsson, Stef ...; Lind, Lars; Li, Shengxu; Sun, Dianjianyi; Spector, Tim D.; Chen, Yii-der Id ...; Damcott, Coleen; Shuldiner, Alan ...; Absher, Devin M.; Horvath, Steve; Tsao, Philip S.; Kardia, Sharon; Psaty, Bruce M.; Sotoodehnia, Non ...; Bell, Jordana T.; Ingelsson, Erik, ...; Chen, Wei; Dehghan, Abbas; Arnett, Donna K.; Waldenberger, Me ...; Hou, Lifang; Whitsel, Eric A.; Baccarelli, Andr ...; Levy, Daniel; Fornage, Myriam; Irvin, Marguerit ...; Assimes, Themist ...; visa färre...

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