WFRF:(Sun Nan)
Sökning: WFRF:(Sun Nan) > Gubenyiliu II Inhib...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04539naa a2200505 4500 | |
| 001 | oai:DiVA.org:uu-330060 | |
| 003 | SwePub | |
| 008 | 171116s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3300602 URI |
| 024 | 7 | a https://doi.org/10.3390/molecules220507872 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhang, Yiu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 245 | 1 0 | a Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways |
| 264 | c 2017-05-15 | |
| 264 | 1 | b MDPI AG,c 2017 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Gubenyiliu II (GYII), a Traditional Chinese Medicine (TCM) formula used in our hospital, has shown beneficial effects in cancer patients. In this study, we investigated the molecular mechanisms underlying the beneficial effects of GYII on murine breast cancer models. GYII showed significant inhibitory effects on tumor growth and metastasis in the murine breast cancer model. Additionally, GYII suppressed the proliferation of 4T1 and MCF-7 cells in a dose-dependent manner. A better inhibitory effect on 4T1 cell proliferation and migration was found in the decomposed recipes (DR) of GYII. Moreover, heparanase expression and the degree of angiogenesis were reduced in tumor tissues. Western blot analysis showed decreased expression of heparanase and growth factors in the cells treated with GYII and its decomposed recipes (DR2 and DR3), and thereby a reduction in the phosphorylation of extracellular signal-regulated kinase (ERK) and serine-threonine kinase (AKT). These results suggest that GYII exerts anti-tumor growth and anti-metastatic effects in the murine breast cancer model. The anti-tumor activity of GYII and its decomposed recipes is, at least partly, associated with decreased heparanase and growth factor expression, which subsequently suppressed the activation of the ERK and AKT pathways. | |
| 650 | 7 | a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng |
| 653 | a Gubenyiliu II | |
| 653 | a breast tumor | |
| 653 | a heparanase | |
| 653 | a growth factors | |
| 653 | a ERK and AKT pathways | |
| 700 | 1 | a Zhang, Gan-Linu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 700 | 1 | a Sun, Xuu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 700 | 1 | a Cao, Ke-Xinu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 700 | 1 | a Shang, Ya-Wenu Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.4 aut |
| 700 | 1 | a Gong, Mu-Xinu Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.4 aut |
| 700 | 1 | a Ma, Congu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 700 | 1 | a Nan, Nanu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 700 | 1 | a Li, Jin-Pingu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut0 (Swepub:uu)jinpili |
| 700 | 1 | a Yu, Ming-Weiu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 700 | 1 | a Yang, Guo-Wangu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 700 | 1 | a Wang, Xiao-Minu Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.4 aut |
| 710 | 2 | a Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing 100010, Peoples R China.b Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.4 org |
| 773 | 0 | t Moleculesd : MDPI AGg 22:5q 22:5x 1431-5157x 1420-3049 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1157733/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.mdpi.com/1420-3049/22/5/787/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330060 |
| 856 | 4 8 | u https://doi.org/10.3390/molecules22050787 |
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