Sökning: WFRF:(Zhang Dongmei) >
Osteoconductive and...
Osteoconductive and Antibacterial Poly(lactic acid) Fibrous Membranes Impregnated with Biobased Nanocarbons for Biodegradable Bone Regenerative Scaffolds
-
- Xu, Huan (författare)
- China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China.
-
- Shen, Mengyuan (författare)
- Xuzhou Med Univ, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China.
-
- Shang, Han (författare)
- China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China.
-
visa fler...
-
- Xu, Wenxuan (författare)
- China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China.
-
- Zhang, Shenghui (författare)
- China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China.
-
- Yang, Hao-Ran (författare)
- Zhengzhou Univ Light Ind, State Lab Surface & Interface Sci & Technol, Sch Mat & Chem Engn, Zhengzhou 450002, Peoples R China.
-
- Zhou, Dongmei (författare)
- Xuzhou Med Univ, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China.
-
- Hakkarainen, Minna (författare)
- KTH,Polymerteknologi
-
visa färre...
-
China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China Xuzhou Med Univ, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China. (creator_code:org_t)
- 2021-08-09
- 2021
- Engelska.
-
Ingår i: Industrial & Engineering Chemistry Research. - : American Chemical Society (ACS). - 0888-5885 .- 1520-5045. ; 60:32, s. 12021-12031
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Carbonaceous nanostructures featuring unique structural characteristics and high cytocompatibility offer a wealth of possibilities to impart enhancements of mechanical properties and biological activities for osteogenic tissue scaffolds. Here, we unveil the fabrication of osteoconductive and antibacterial porous poly(lactic acid) (PLA) membranes by direct electrospinning of microfibers impregnated with coffee-ground-derived quantum dots (QDs). It enabled a straightforward pathway to regulate the diameter and its distribution for the electrospun PLA microfibers, as well as the improved hydrophilicity. The QDs exhibited high affinity to the PLA matrix, permitting remarkable promotion of tensile strength and elastic modulus for the QD-modified PLA membranes while maintaining comparable extensibility. More importantly, osteoblast adhesion and stretching on the electrospun membranes were significantly enhanced with the existence of QDs, as exemplified by the nearly 1.8-fold increase in cell viability cultured onto the composite membrane loaded with 1.5% QDs compared to that of pure PLA. This was accompanied by rapid biomimetic mineralization and uniform apatite formation in an osteofriendly manner. Unexpectedly, immediate and broad-spectrum antibacterial performance was achieved for the composite membranes, likely arising from the synergistic effects of QD-imparted membrane stress and oxidative stress. The unusual combination of mechanical, biomineralization, biological, and antibacterial performances makes the biodegradable membrane scaffolds promising for guided bone/tissue regeneration therapy.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas