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  • Canelas, A.B.Technische Universiteit Delft,Delft University of Technology (TU Delft) (author)

Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-12-21
  • Springer Science and Business Media LLC,2010

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:ae4f8bca-0d68-4e50-9fd9-977bbcc31d8e
  • https://research.chalmers.se/publication/138435URI
  • https://doi.org/10.1038/ncomms1150DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The field of systems biology is often held back by difficulties in obtaining comprehensive, high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to generate such a data set for a very large number of cellular components in the yeast Saccharomyces cerevisiae, a widely used model organism that is also used in the production of fuels, chemicals, food ingredients and pharmaceuticals. With the current focus on biofuels and sustainability, there is much interest in harnessing this species as a general cell factory. In this study, we characterized two yeast strains, under two standard growth conditions. We ensured the high quality of the experimental data by evaluating a wide range of sampling and analytical techniques. Here we show significant differences in the maximum specific growth rate and biomass yield between the two strains. On the basis of the integrated analysis of the high-throughput data, we hypothesize that differences in phenotype are due to differences in protein metabolism.

Subject headings and genre

  • NATURVETENSKAP Kemi hsv//swe
  • NATURAL SCIENCES Chemical Sciences hsv//eng
  • Switzerland.
  • F-75700
  • UMR 5800
  • fermentative capacity
  • -8093 Zurich
  • quantitative-analysis
  • saccharomyces-cerevisiae strains
  • network
  • extraction
  • minimum information
  • glycolytic-enzymes
  • David] CNRS
  • metabolomics
  • chemostat cultures
  • genome
  • [Sherman
  • Lab Bordelais Rech Informat

Added entries (persons, corporate bodies, meetings, titles ...)

  • Harrison, N.University Of Cambridge (author)
  • Fazio, A.Danmarks Tekniske Universitet,Technical University of Denmark (author)
  • Zhang, Jie,1981Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)zjie (author)
  • Pitkanen, J. P.Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT) (author)
  • van den Brink, J.Technische Universiteit Delft,Delft University of Technology (TU Delft) (author)
  • Bakker, B.M.Vrije Universiteit Amsterdam (VU) (author)
  • Bogner, L.Universität Stuttgart,University of Stuttgart (author)
  • Bouwman, J.Vrije Universiteit Amsterdam (VU) (author)
  • Castrillo, J. I.University Of Cambridge (author)
  • Cankorur, A.Bogazici Universitesi,Bogazici University (author)
  • Chumnanpuen, Pramote,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)pramote (author)
  • Daran-Lapujade, P.Technische Universiteit Delft,Delft University of Technology (TU Delft) (author)
  • Dikicioglu, D.Bogazici Universitesi,Bogazici University (author)
  • Van Eunen, K.Vrije Universiteit Amsterdam (VU) (author)
  • Ewald, J. C.Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH) (author)
  • Heijnen, J.J.Technische Universiteit Delft,Delft University of Technology (TU Delft) (author)
  • Kirdar, B.Bogazici Universitesi,Bogazici University (author)
  • Mattila, I.Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT) (author)
  • Mensonides, F.I.Vrije Universiteit Amsterdam (VU) (author)
  • Niebel, A.Universität Stuttgart,University of Stuttgart (author)
  • Penttila, M.Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT) (author)
  • Pronk, J.Technische Universiteit Delft,Delft University of Technology (TU Delft) (author)
  • Reuss, M.Universität Stuttgart,University of Stuttgart (author)
  • Salusjarvi, L.Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT) (author)
  • Sauer, Uwe H.Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH) (author)
  • Sherman, D.Centre national de la recherche scientifique (CNRS) (author)
  • Siemann-Herzberg, M.Universität Stuttgart,University of Stuttgart (author)
  • Westerhoff, H.V.Vrije Universiteit Amsterdam (VU) (author)
  • de Winde, J.H.Technische Universiteit Delft,Delft University of Technology (TU Delft) (author)
  • Petranovic Nielsen, Dina,1975Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)dinap (author)
  • Oliver, S. G.University Of Cambridge (author)
  • Workman, C. T.Danmarks Tekniske Universitet,Technical University of Denmark (author)
  • Zamboni, N.Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH) (author)
  • Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Technische Universiteit DelftUniversity Of Cambridge (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC1:92041-17232041-1723

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