Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes.

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Fältnamn	Indikatorer	Metadata
000		02953naa a2200325 4500
001		oai:DiVA.org:uu-318402
003		SwePub
008		220117s1989 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3184022 URI
024	7	a https://doi.org/10.1038/jcbfm.1989.732 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Grøgaard, B4 aut
245	1 0	a Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes.
264		c 2016-06-29
264	1	b SAGE Publications,c 1989
338		a print2 rdacarrier
520		a The role of polymorphonuclear leukocytes (PMNLs) in postischemic delayed hypoperfusion in the rat brain was investigated. Cerebral ischemia was accomplished by reversible bilateral occlusion of the common carotid arteries for 15 min combined with bleeding to an MABP of 50 mm Hg. The animals of one group were depleted of their circulating. PMNLs by intraperitoneal injections of an antineutrophil serum (ANS) prior to the experiment. All animals included in this group had fewer than 0.2 x 10(9) circulating PMNLs/L at the start of the experiments. In another group ANS was injected intravenously for 5 min starting 2 min after the ischemic insult. After 4 min of recirculation, the number of circulating PMNLs in this group was below 10% of the normal. Control animals were injected with the same amount of normal sheep serum or were not treated at all. Sixty minutes after termination of ischemia, the local blood flow in previously ischemic cerebral structures was 40-50% of the normal as measured with the [14C]iodoantipyrine technique. In animals treated with ANS prior to the ischemic insult, the postischemic blood flow in the frontal, sensorimotor, and parietal cortex as well as caudoputamen and thalamus was significantly higher than that in non-ANS-treated animals. Treatment with ANS immediately after the ischemic period caused no improvement of the local CBF. It is concluded that PMNLs are involved in the cerebral postischemic flow derangements seen in this model. Their effects seem to be exerted during ischemia or immediately upon reinstitution of blood flow.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
700	1	a Schürer, L4 aut
700	1	a Gerdin, Bengt,d 1947-4 aut
700	1	a Arfors, K E4 aut
773	0	t Journal of Cerebral Blood Flow and Metabolismd : SAGE Publicationsg 9:4, s. 500-5q 9:4<500-5x 0271-678Xx 1559-7016
856	4	u http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1989.73
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318402
856	4 8	u https://doi.org/10.1038/jcbfm.1989.73

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Av författaren/redakt...: Grøgaard, B; Schürer, L; Gerdin, Bengt, 1 ...; Arfors, K E

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Fysiologi

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Av lärosätet: Uppsala universitet

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