Early-Life Cardiorespiratory Fitness and Long-term Risk of Prostate Cancer

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Fältnamn	Indikatorer	Metadata
000		04624naa a2200373 4500
001		oai:DiVA.org:uu-428992
003		SwePub
008		201218s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4289922 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-20-05352 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Crump, Caseyu Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA4 aut
245	1 0	a Early-Life Cardiorespiratory Fitness and Long-term Risk of Prostate Cancer
264	1	c 2020
338		a print2 rdacarrier
520		a Background: Adolescence is a period of rapid prostatic growth, yet is understudied for susceptibility for future risk of prostate cancer. We examined cardiorespiratory fitness (CRF) in late adolescence in relation to long-term prostate cancer risk.Methods: A population-based cohort study was conducted of all 699,125 Swedish military conscripts during 1972–1985 (97%–98% of 18-year-old men) in relation to risk of prostate cancer overall, aggressive prostate cancer, and prostate cancer mortality during 1998–2017 (ages 50–65 years). CRF was measured by maximal aerobic workload, and prostate cancer was ascertained using the National Prostate Cancer Register. Muscle strength was examined as a secondary predictor.Results: In 38.8 million person-years of follow-up, 10,782 (1.5%) men were diagnosed with prostate cancer. Adjusting for sociodemographic factors, height, weight, and family history of prostate cancer, high CRF was associated with a slightly increased risk of any prostate cancer [highest vs. lowest quintile: incidence rate ratio (IRR), 1.10; 95% CI, 1.03–1.19; P = 0.008], but was neither significantly associated with aggressive prostate cancer (1.01; 0.85–1.21; P = 0.90) nor prostate cancer mortality (1.24; 0.73–2.13; P = 0.42). High muscle strength also was associated with a modestly increased risk of any prostate cancer (highest vs. lowest quintile: IRR, 1.14; 95% CI, 1.07–1.23; P < 0.001), but neither with aggressive prostate cancer (0.88; 0.74–1.04; P = 0.14) nor prostate cancer mortality (0.81; 0.48–1.37; P = 0.43).Conclusions: High CRF or muscle strength in late adolescence was associated with slightly increased future risk of prostate cancer, possibly related to increased screening, but neither with risk of aggressive prostate cancer nor prostate cancer mortality.Impact: These findings illustrate the importance of distinguishing aggressive from indolent prostate cancer and assessing for potential detection bias.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
700	1	a Stattin, Päru Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)parst892
700	1	a Brooks, James D.u Stanford Univ, Sch Med, Dept Urol, Stanford, CA 94305 USA4 aut
700	1	a Stocks, Tanjau Lund Univ, Dept Clin Sci Lund, Lund, Sweden4 aut
700	1	a Sundquist, Janu Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA; Lund Univ, Ctr Primary Hlth Care Res, Malmö, Sweden4 aut
700	1	a Sieh, Weivau Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA4 aut
700	1	a Sundquist, Kristinau Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA; Lund Univ, Ctr Primary Hlth Care Res, Malmö, Sweden4 aut
710	2	a Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USAb Urologkirurgi4 org
773	0	t Cancer Epidemiology, Biomarkers and Preventiong 29:11, s. 2187-2194q 29:11<2187-2194x 1055-9965x 1538-7755
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428992
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-20-0535

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Av författaren/redakt...: Crump, Casey; Stattin, Pär; Brooks, James D.; Stocks, Tanja; Sundquist, Jan; Sieh, Weiva; visa fler...; Sundquist, Krist ...; visa färre...

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