Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products

Dry powder inhalers : An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products

Velaga, Sitaram (författare): Luleå tekniska universitet,Medicinsk vetenskap

Djuris, Jelena (författare): Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy

Cvijic, Sandra (författare): Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy

Colombo, Gaia (författare): Department of Life Sciences and Biotechnology, University of Ferrara

Rossi, Alessandra (författare): Food and Drug Department, University of Parma

(creator_code:org_t)

Elsevier, 2018
2018
Engelska.
Ingår i: European Journal of Pharmaceutical Sciences. - : Elsevier. - 0928-0987 .- 1879-0720. ; 113, s. 18-28

Relaterad länk:: https://iris.unife.i...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated.The review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhaler, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent bio-relevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Annan hälsoveten ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.