Search: WFRF:(Courtney M. J.) > (2015-2019) > A combination of pl...
Fältnamn | Indikatorer | Metadata |
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000 | 08430naa a2200913 4500 | |
001 | oai:DiVA.org:umu-141998 | |
003 | SwePub | |
008 | 171121s2017 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:e121d8bd-6565-4e17-b9ed-14776c97f608 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1419982 URI |
024 | 7 | a https://doi.org/10.1371/journal.pmed.10024092 DOI |
024 | 7 | a https://lup.lub.lu.se/record/e121d8bd-6565-4e17-b9ed-14776c97f6082 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Imamura, Fumiakiu University of Cambridge4 aut |
245 | 1 0 | a A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes :b The EPIC-InterAct case-cohort study |
264 | c 2017-10-11 | |
264 | 1 | b Public Library Science,c 2017 |
338 | a electronic2 rdacarrier | |
520 | a Background Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated.Methods and findings We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested casecohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of.-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19-0.29) adjusted for potential confounders and 0.37 (95% CI 0.27-0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p < 0.05 each). Limitations include potential measurement error in the fatty acids and other model covariates and possible residual confounding.Conclusions A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D. The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Sharp, Stephen J.u University of Cambridge4 aut |
700 | 1 | a Koulman, Albertu MRC Human Nutrition Research,University of Cambridge4 aut |
700 | 1 | a Schulze, Matthias B.u German Institute of Human Nutrition,University of Paris-Saclay4 aut |
700 | 1 | a Kröger, Janineu German Institute of Human Nutrition4 aut |
700 | 1 | a Griffin, Julian L.u University of Cambridge4 aut |
700 | 1 | a Huerta, José M.u CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Guevara, Marcelau CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Sluijs, Ivonneu University Medical Center Utrecht4 aut |
700 | 1 | a Agudo, Antoniou Catalan Institute of Oncology4 aut |
700 | 1 | a Ardanaz, Evau CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Balkau, Beverley4 aut |
700 | 1 | a Boeing, Heineru German Institute of Human Nutrition4 aut |
700 | 1 | a Chajes, Veroniqueu International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Dahm, Christina C.u Aarhus University4 aut |
700 | 1 | a Dow, Courtneyu Institut Gustave Roussy,University of Paris-Saclay4 aut |
700 | 1 | a Fagherazzi, Guyu University of Paris-Saclay,Institut Gustave Roussy4 aut |
700 | 1 | a Feskens, Edith J. M.u Wageningen University4 aut |
700 | 1 | a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Allmänmedicin,Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Gavrila, Dianau CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council,Hospital Virgen de la Arrixaca4 aut |
700 | 1 | a Gunter, Marcu Aarhus University4 aut |
700 | 1 | a Kaaks, Rudolfu German Cancer Research Centre4 aut |
700 | 1 | a Key, Timothy J.u University of Oxford4 aut |
700 | 1 | a Khaw, Kay-Teeu University of Cambridge4 aut |
700 | 1 | a Kuehn, Tilmanu German Cancer Research Centre4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Molina-Portillo, Elenau University of Granada,CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Nilsson, Peter M.u University of Cambridge4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Olsen, Anjau Danish Cancer Society4 aut |
700 | 1 | a Overvad, Kimu Aarhus University,Aarhus University Hospital4 aut |
700 | 1 | a Palli, Domenicou Cancer Research and Prevention Institute (ISPO)4 aut |
700 | 1 | a Panico, Salvatoreu University of Naples Federico II4 aut |
700 | 1 | a Rolandsson, Olovu Umeå University,Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005 |
700 | 1 | a Sieri, Sabinau Istituto Nazionale dei Tumori4 aut |
700 | 1 | a Sacerdote, Carlottau Citta' della Salute e della Scienza Hospital-University of Turin4 aut |
700 | 1 | a Slimani, Nadiau International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Spijkerman, Annemieke M. W.u National Institute for Public Health and the Environment (RIVM)4 aut |
700 | 1 | a Tjønneland, Anneu Danish Cancer Society4 aut |
700 | 1 | a Tumino, Rosariou Civic and M.P Arezzo Hospital4 aut |
700 | 1 | a van der Schouw, Yvonne T.u University Medical Center Utrecht4 aut |
700 | 1 | a Langenberg, Claudiau University of Cambridge4 aut |
700 | 1 | a Riboli, Eliou Imperial College London4 aut |
700 | 1 | a Forouhi, Nita G.u University of Cambridge4 aut |
700 | 1 | a Wareham, Nick J.u University of Cambridge4 aut |
710 | 2 | a University of Cambridgeb MRC Human Nutrition Research4 org |
773 | 0 | t PLoS Medicined : Public Library Scienceg 14:10q 14:10x 1549-1277x 1549-1676 |
856 | 4 | u https://doi.org/10.1371/journal.pmed.1002409y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1159046/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002409&type=printable |
856 | 4 | u http://dx.doi.org/10.1371/journal.pmed.1002409x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141998 |
856 | 4 8 | u https://doi.org/10.1371/journal.pmed.1002409 |
856 | 4 8 | u https://lup.lub.lu.se/record/e121d8bd-6565-4e17-b9ed-14776c97f608 |
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