Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden

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Fältnamn	Indikatorer	Metadata
000		04393naa a2200469 4500
001		oai:DiVA.org:uu-313419
003		SwePub
008		170119s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3134192 URI
024	7	a https://doi.org/10.3899/jrheum.1603032 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a ElShafie, Amir Ibrahim,d 1970-u Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)amiel226
245	1 0	a Active Rheumatoid Arthritis in Central Africa :b A Comparative Study Between Sudan and Sweden
264		c 2016-08-01
264	1	b The Journal of Rheumatology,c 2016
338		a electronic2 rdacarrier
520		a Objective. To compare clinical characteristics and treatment between simultaneously investigated Sudanese and Swedish outpatients with rheumatoid arthritis (RA).Methods. Outpatients with RA from Sudan (n = 281) and Sweden (n = 542) diagnosed according to the 1987 American College of Rheumatology criteria were recruited between December 2008 and September 2010 and compared concerning clinical presentation, treatment, and laboratory findings, including immunoglobulin M with rheumatoid factor (IgM-RF).Results. Sudanese patients had lower inclusion age (median 49 vs 68 yrs), disease duration (48 vs 107 mos), and disease onset age (43 vs 56 yrs) as compared with Swedish patients (p < 0.0001 for all). When stratified concerning the age of inclusion, Swedish patients between 41-50 years had, however, a significantly lower age of onset, with a similar trend for all age groups above 30 years. The female preponderance was higher among Sudanese patients (89.3% vs 72.5%, p < 0.0001), and smoking was nonexistent among Sudanese female patients (p < 0.0001). Erythrocyte sedimentation rate levels and number of tender joints were significantly higher among Sudanese patients. The proportion of IgM-RF positivity was lower among Sudanese patients with RA (52.4% vs 75.5%, p < 0.0001). Higher proportions of Sudanese patients with RA were treated with methotrexate (MTX) and disease-modifying antirheumatic drug combinations, but none of them used biologics. Sudanese patients used lower doses of MTX and sulfasalazine (p < 0.0001) and higher doses of prednisolone (p < 0.0001) than Swedish patients.Conclusion. Sudanese patients with RA have significantly higher disease activity and are often IgM-RF-seronegative. Together with reports from Uganda and Cameroon, our data indicate a cluster of highly active and often seronegative RA in central Africa.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653		a RHEUMATOID ARTHRITIS
653		a SUDAN
653		a DISEASE SEVERITY
653		a RHEUMATOID FACTOR
653		a DISEASE-MODIFYING ANTIRHEUMATIC DRUGS
700	1	a Elkhalifa, Abdalla D.u Gavle Cent Hosp, Rheumatol Unit, Gavle, Sweden.4 aut
700	1	a Elbagir, Sahwau Uppsala universitet,Klinisk immunologi,Khartoum Fertil Ctr, Khartoum, Sudan.4 aut0 (Swepub:uu)sahel165
700	1	a Aledrissy, Mawahib I. E.u Alribat Univ Hosp, Rheumatol Unit, Khartoum, Sudan.4 aut
700	1	a Elagib, Elnour M.u Mil Hosp, Rheumatol Unit, Omdurman, Sudan.4 aut
700	1	a Nur, Musa A. M.u Alribat Univ Hosp, Rheumatol Unit, Khartoum, Sudan.4 aut
700	1	a Weitoft, Tomasu Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Gavle Cent Hosp, Rheumatol Unit, Gavle, Sweden4 aut0 (Swepub:uu)tomwe626
700	1	a Rönnelid, Johanu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)joharonn
710	2	a Uppsala universitetb Klinisk immunologi4 org
773	0	t Journal of Rheumatologyd : The Journal of Rheumatologyg 43:10, s. 1777-1786q 43:10<1777-1786x 0315-162Xx 1499-2752
856	4	u https://doi.org/10.3899/jrheum.160303y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1068560/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.jrheum.org/content/jrheum/43/10/1777.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-313419
856	4 8	u https://doi.org/10.3899/jrheum.160303

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