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FältnamnIndikatorerMetadata
00007516naa a2200913 4500
001oai:lup.lub.lu.se:ab62fec5-4647-4e40-9c36-2775254be19e
003SwePub
008160401s2007 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-20694
009oai:prod.swepub.kib.ki.se:115974015
009oai:gup.ub.gu.se/58590
009oai:DiVA.org:uu-143335
0247 a https://lup.lub.lu.se/record/6085082 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206942 URI
0247 a https://doi.org/10.1056/NEJMoa0732042 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1159740152 URI
0247 a https://gup.ub.gu.se/publication/585902 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1433352 URI
040 a (SwePub)lud (SwePub)umud (SwePub)kid (SwePub)gud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Naucler, Pontusu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-pun
2451 0a Human papillomavirus and Papanicolaou tests to screen for cervical cancer.
264 1a Boston, Massachusetts :b Massachusetts medical society,c 2007
520 a Background Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical epithelial neoplasia or cervical cancer is unknown. Methods In a population-based screening program in Sweden, 12,527 women 32 to 38 years of age were randomly assigned at a 1:1 ratio to have an HPV test plus a Papanicolaou (Pap) test (intervention group) or a Pap test alone (control group). Women with a positive HPV test and a normal Pap test result were offered a second HPV test at least 1 year later, and those who were found to be persistently infected with the same high-risk type of HPV were then offered colposcopy with cervical biopsy. A similar number of double-blinded Pap smears and colposcopies with biopsy were performed in randomly selected women in the control group. Comprehensive registry data were used to follow the women for a mean of 4.1 years. The relative rates of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected at enrollment and at subsequent screening examinations were calculated. Results At enrollment, the proportion of women in the intervention group who were found to have lesions of grade 2 or 3 cervical intraepithelial neoplasia or cancer was 51% greater (95% confidence interval [CI], 13 to 102) than the proportion of women in the control group who were found to have such lesions. At subsequent screening examinations, the proportion of women in the intervention group who were found to have grade 2 or 3 lesions or cancer was 42% less (95% CI, 4 to 64) and the proportion with grade 3 lesions or cancer was 47% less (95% CI, 2 to 71) than the proportions of control women who were found to have such lesions. Women with persistent HPV infection remained at high risk for grade 2 or 3 lesions or cancer after referral for colposcopy. Conclusions The addition of an HPV test to the Pap test to screen women in their mid-30s for cervical cancer reduces the incidence of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected by subsequent screening examinations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a Adult
653 a Cervical Intraepithelial Neoplasia: diagnosis
653 a Cervical Intraepithelial Neoplasia: pathology
653 a Cervical Intraepithelial Neoplasia: prevention & control
653 a DNA
653 a Colposcopy
653 a Sensitivity and Specificity
653 a Polymerase Chain Reaction
653 a Papillomavirus Infections: diagnosis
653 a Papillomaviridae: isolation & purification
653 a Mass Screening
653 a Papillomaviridae: genetics
653 a Vaginal Smears
653 a Viral: analysis
653 a Double-Blind Method
653 a Female
653 a Humans
653 a Uterine Cervical Neoplasms: diagnosis
653 a Uterine Cervical Neoplasms: prevention & control
653 a Uterine Cervical Neoplasms: pathology
653 a 
653 a control
653 a Viral/*analysis
653 a Papillomaviridae/genetics/*isolation & purification
653 a Papillomavirus Infections/*diagnosis
653 a Uterine Cervical Neoplasms/*diagnosis/pathology/prevention & control
653 a *Vaginal Smears
653 a MEDICINE
7001 a Ryd, Walteru Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology4 aut
7001 a Tornberg, Svenu Karolinska Institutet4 aut
7001 a Strand, Andersu Uppsala universitet,Dermatologi och venereologi4 aut0 (Swepub:uu)andestra
7001 a Wadell, Göranu Umeå universitet,Virologi4 aut0 (Swepub:umu)gowa0001
7001 a Elfgren, Kristina4 aut
7001 a Radberg, Thomasu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut
7001 a Strander, Björn,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut0 (Swepub:gu)xstrbj
7001 a Forslund, Olau Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-ofo
7001 a Hansson, Bengt-Göranu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-bha
7001 a Rylander, Evau Karolinska Institutet4 aut
7001 a Dillner, Joakimu Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-jdi
7001 a Johansson, Bo4 aut
7102 a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t New England Journal of Medicined Boston, Massachusetts : Massachusetts medical societyg 357:16, s. 1589-97q 357:16<1589-1597x 0028-4793x 1533-4406
7730 t N Engl J Medd Boston, Massachusetts : Massachusetts medical societyg 357:16, s. 1589-97q 357:16<1589-97
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17942872&dopt=Abstracty FULLTEXT
8564 8u https://lup.lub.lu.se/record/608508
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-20694
8564 8u https://doi.org/10.1056/NEJMoa073204
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:115974015
8564 8u https://gup.ub.gu.se/publication/58590
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-143335

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