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Short peptide analo...
Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants
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- Jangamreddy, Jaganmohan (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,LV Prasad Eye Inst, India
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- Haagdorens, Michel K.C. (author)
- Dept. of Ophthalmology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Antwerp, Belgium; Faculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Antwerp, Belgium,Antwerp Univ Hosp, Belgium; Univ Antwerp, Belgium
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- Mirazul Islam, Mohammad Mirazul (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Lewis, Philip (author)
- Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Wales CF24 4HQ, UK,Cardiff Univ, Wales
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- Samanta, Ayan (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Fagerholm, Per (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Liszka, Aneta (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Kozak Ljunggren, Monika (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Buznyk, Oleksiy (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Alarcon, Emilio I. (author)
- Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada,Univ Ottawa, Canada
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- Zakaria, Nadia (author)
- Dept. of Ophthalmology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Antwerp, Belgium; Faculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Antwerp, Belgium,Antwerp Univ Hosp, Belgium; Univ Antwerp, Belgium
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- Meek, Keith M. (author)
- Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Wales CF24 4HQ, UK,Cardiff Univ, Wales
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- Griffith, May (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Univ Montreal, Canada; Univ Montreal, Canada
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- English.
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In: Acta Biomaterialia. - : Elsevier. - 1742-7061 .- 1878-7568. ; 69, s. 120-130
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Abstract
Subject headings
Close
- Short collagen-like peptides (CLPs) are being proposed as alternatives to full-length collagen for use in tissue engineering, on their own as soft hydrogels, or conjugated to synthetic polymer for mechanical strength. However, despite intended clinical use, little is known about their safety and efficacy, mechanism of action or degree of similarity to the full-length counterparts they mimic. Here, we show the functional equivalence of a CLP conjugated to polyethylene glycol (CLP-PEG) to full-length recombinant human collagen in vitro and in promoting stable regeneration of corneal tissue and nerves in a preclinical mini-pig model. We also show that these peptide analogs exerted their pro-regeneration effects through stimulating extracellular vesicle production by host cells. Our results support future use of CLP-PEG implants for corneal regeneration, suggesting the feasibility of these or similar peptide analogs in clinical application in the eye and other tissues.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- Collagen-like peptide; Recombinant human collagen; Cornea; Regeneration; Exosomes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jangamreddy, Jag ...
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Haagdorens, Mich ...
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Mirazul Islam, M ...
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Lewis, Philip
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Samanta, Ayan
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Fagerholm, Per
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show more...
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Liszka, Aneta
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Kozak Ljunggren, ...
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Buznyk, Oleksiy
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Alarcon, Emilio ...
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Zakaria, Nadia
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Meek, Keith M.
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Griffith, May
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
- Articles in the publication
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Acta Biomaterial ...
- By the university
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Uppsala University
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Linköping University