WFRF:(Jeliazkova Nina)
Sökning: WFRF:(Jeliazkova Nina) > Computational toxic...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04511naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-160867 | |
| 003 | SwePub | |
| 008 | 111102s2011 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:222075173 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1608672 URI |
| 024 | 7 | a https://doi.org/10.1186/1756-0500-4-4872 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2220751732 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Willighagen, Egonu Karolinska Institutet,Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)egowi213 |
| 245 | 1 0 | a Computational toxicology using the OpenTox application programming interface and Bioclipse |
| 264 | c 2011-11-10 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Toxicity is a complex phenomenon involving the potential adverse effect on a range of biological functions. Predicting toxicity involves using a combination of experimental data (endpoints) and computational methods to generate a set of predictive models. Such models rely strongly on being able to integrate information from many sources. The required integration of biological and chemical information sources requires, however, a common language to express our knowledge ontologically, and interoperating services to build reliable predictive toxicology applications. Findings: This article describes progress in extending the integrative bio- and cheminformatics platform Bioclipse to interoperate with OpenTox, a semantic web framework which supports open data exchange and toxicology model building. The Bioclipse workbench environment enables functionality from OpenTox web services and easy access to OpenTox resources for evaluating toxicity properties of query molecules. Relevant cases and interfaces based on ten neurotoxins are described to demonstrate the capabilities provided to the user. The integration takes advantage of semantic web technologies, thereby providing an open and simplifying communication standard. Additionally, the use of ontologies ensures proper interoperation and reliable integration of toxicity information from both experimental and computational sources. Conclusions: A novel computational toxicity assessment platform was generated from integration of two open science platforms related to toxicology: Bioclipse, that combines a rich scriptable and graphical workbench environment for integration of diverse sets of information sources, and OpenTox, a platform for interoperable toxicology data and computational services. The combination provides improved reliability and operability for handling large data sets by the use of the Open Standards from the OpenTox Application Programming Interface. This enables simultaneous access to a variety of distributed predictive toxicology databases, and algorithm and model resources, taking advantage of the Bioclipse workbench handling the technical layers. | |
| 650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
| 653 | a Bioinformatik | |
| 653 | a Bioinformatics | |
| 700 | 1 | a Jeliazkova, Ninau Ideaconsult Ltd4 aut |
| 700 | 1 | a Hardy, Barryu Douglas Connect4 aut |
| 700 | 1 | a Grafström, Rolandu Karolinska Institutet4 aut |
| 700 | 1 | a Spjuth, Ola,d 1977-u Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmaceutisk bioinformatik4 aut0 (Swepub:uu)olspj499 |
| 710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
| 773 | 0 | t BMC Research Notesd : Springer Science and Business Media LLCg 4:1, s. 487-q 4:1<487-x 1756-0500 |
| 856 | 4 | u http://www.biomedcentral.com/1756-0500/4/487/abstract |
| 856 | 4 | u https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-4-487 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160867 |
| 856 | 4 8 | u https://doi.org/10.1186/1756-0500-4-487 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:222075173 |
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