Sex Differences in the Effect of Vitamin D on Fatigue in Palliative Cancer Care: A Post Hoc Analysis of the Randomized, Controlled Trial 'Palliative-D'

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Klasson Anna) > Sex Differences in ...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03965naa a2200529 4500
001		oai:DiVA.org:esh-9428
003		SwePub
008		220329s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:148828273
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-94282 URI
024	7	a https://doi.org/10.3390/cancers140307462 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1488282732 URI
040		a (SwePub)eshd (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Klasson, Carithau Karolinska Institutet,Karolinska institutet4 aut
245	1 0	a Sex Differences in the Effect of Vitamin D on Fatigue in Palliative Cancer Care :b A Post Hoc Analysis of the Randomized, Controlled Trial 'Palliative-D'
264		c 2022-01-31
264	1	b MDPI AG,c 2022
338		a print2 rdacarrier
500		a Forskningsfinansiärer:CIMED (centrum för innovativ medicin) ASIH Stockholm Norr
520		a In the randomized, placebo-controlled, double-blind trial 'Palliative-D', vitamin D treatment of 4000 IE/day for 12 weeks reduced opioid use and fatigue in vitamin-D-deficient cancer patients. In screening data from this trial, lower levels of vitamin D were associated with more fatigue in men but not in women. The aim of the present study was to investigate possible sex differences in the effect of vitamin D in patients with advanced cancer, with a specific focus on fatigue. A post hoc analysis of sex differences in patients completing the Palliative-D study (n = 150) was performed. Fatigue assessed with the Edmonton Symptom Assessment Scale (ESAS) was reduced in vitamin-D-treated men; -1.50 ESAS points (95%CI -2.57 to -0.43; p = 0.007) but not in women; -0.75 (95%CI -1.85 to 0.36; p = 0.18). Fatigue measured with EORTC QLQ-C15-PAL had a borderline significant effect in men (-0.33 (95%CI -0.67 to 0.03; p = 0.05)) but not in women (p = 0.55). The effect on fatigue measured with ESAS in men remained the same after adjustment for opioid doses (p = 0.01). In conclusion, the positive effect of the correction of vitamin D deficiency on fatigue may be more pronounced in men than in women. However, studies focused on analyzing sex differences in this context must be performed before firm conclusions can be drawn.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Omvårdnad0 (SwePub)303052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nursing0 (SwePub)303052 hsv//eng
653		a Edmonton Symptom Assessment Scale (ESAS)
653		a European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 for Palliative Care (EORTC QLQ-C15-PAL)
653		a cancer
653		a fatigue
653		a palliative
653		a randomized clinical trial
653		a sex differences
653		a vitamin D
700	1	a Helde Frankling, Mariau Karolinska Institutet,Karolinska institutet; Karolinska universitetssjukhuset4 aut
700	1	a Warnqvist, Annau Karolinska Institutet,Karolinska institutet4 aut
700	1	a Sandberg, Carinau Stockholms sjukhem4 aut
700	1	a Nordström, Marieu Stockholms sjukhem4 aut
700	1	a Lundh Hagelin, Carinau Ersta Sköndal Bräcke högskola,Institutionen för vårdvetenskap,Karolinska institutet4 aut0 (Swepub:esh)carlun
700	1	a Björkhem-Bergman, Lindau Karolinska institutet; Stockholms sjukhem4 aut
710	2	a Karolinska Institutetb Karolinska institutet4 org
773	0	t Cancersd : MDPI AGg 14:3q 14:3x 2072-6694
856	4	u https://doi.org/10.3390/cancers14030746y Fulltext
856	4	u https://www.mdpi.com/2072-6694/14/3/746/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-9428
856	4 8	u https://doi.org/10.3390/cancers14030746
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:148828273

Hitta via bibliotek

Cancers (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Klasson, Caritha; Helde Frankling, ...; Warnqvist, Anna; Sandberg, Carina; Nordström, Marie; Lundh Hagelin, C ...; visa fler...; Björkhem-Bergman ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Omvårdnad

Artiklar i publikationen: Cancers

Av lärosätet: Marie Cederschiöld högskola; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se