Vector competence of Swedish Culex pipiens mosquitos for Japanese Encephalitis Virus

Krambrich, JaninaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi (författare)

Japanese encephalitis virus (JEV) is an emerging mosquito-borne Orthoflavivirus that poses a significant public health concern in many temperate and tropical regions in Asia. Since the climate in some endemic countries is similar to temperate climates observed in Europe, understanding the role of specific mosquito species in the transmission of JEV is essential for predicting and effectively controlling the potential for an introduction and establishment of JEV in Europe. This study aimed to investigate the vector competence of colonized Culex pipiens biotype molestus mosquitoes for JEV. The mosquitoes were initially collected from the field in southern Sweden. The mosquitoes were offered a blood meal containing the Nakayama strain of JEV (genotype III), and infection rates (IR), dissemination rates (DR), and transmission rates (TR) were evaluated at 14, 21, and 28 days post-feeding. The study revealed that colonized Swedish Cx. pipiens are susceptible to JEV infection, with stable IR of around 10% at all time-points. However, virus was only detected in the legs of one mosquito at 21 days post feeding, and no mosquito saliva contained JEV. Overall, this research shows that Swedish Cx. pipiens can become infected with JEV, and emphasizes the importance of further understanding the thresholds and barriers for JEV dissemination in mosquitoes.

Akaberi, DarioUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi (författare)
Lindahl, Johanna F.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi (författare)
Lundkvist, ÅkeUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi (författare)
Hesson, Jenny C.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi (författare)
Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

Av författaren/redakt...: Krambrich, Janin ...; Akaberi, Dario; Lindahl, Johanna ...; Lundkvist, Åke; Hesson, Jenny C.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

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