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WFRF:(Li Jian Fang)
 

Sökning: WFRF:(Li Jian Fang) > (2015-2019) > Transcriptional lan...

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FältnamnIndikatorerMetadata
00006724naa a2200697 4500
001oai:lup.lub.lu.se:26dd769e-7441-41b5-8b35-a9ee3b58942e
003SwePub
008190103s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/26dd769e-7441-41b5-8b35-a9ee3b58942e2 URI
0247 a https://doi.org/10.1073/pnas.18143971152 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Li, Jian Fengu Ruijin Hospital,Shanghai Jiao Tong University4 aut
2451 0a Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases
264 c 2018-11-28
264 1b Proceedings of the National Academy of Sciences,c 2018
520 a Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion of BCP ALL remains poorly characterized in relation to its underlying genomic abnormalities. We therefore initiated a large-scale international study to reanalyze and delineate the transcriptome landscape of 1,223 BCP ALL cases using RNA sequencing. Fourteen BCP ALL gene expression subgroups (G1 to G14) were identified. Apart from extending eight previously described subgroups (G1 to G8 associated with MEF2D fusions, TCF3–PBX1 fusions, ETV6–RUNX1–positive/ETV6–RUNX1–like, DUX4 fusions, ZNF384 fusions, BCR–ABL1/Ph–like, high hyperdiploidy, and KMT2A fusions), we defined six additional gene expression subgroups: G9 was associated with both PAX5 and CRLF2 fusions; G10 and G11 with mutations in PAX5 (p.P80R) and IKZF1 (p.N159Y), respectively; G12 with IGH–CEBPE fusion and mutations in ZEB2 (p.H1038R); and G13 and G14 with TCF3/4–HLF and NUTM1 fusions, respectively. In pediatric BCP ALL, subgroups G2 to G5 and G7 (51 to 65/67 chromosomes) were associated with low-risk, G7 (with ≤50 chromosomes) and G9 were intermediate-risk, whereas G1, G6, and G8 were defined as high-risk subgroups. In adult BCP ALL, G1, G2, G6, and G8 were associated with high risk, while G4, G5, and G7 had relatively favorable outcomes. This large-scale transcriptome sequence analysis of BCP ALL revealed distinct molecular subgroups that reflect discrete pathways of BCP ALL, informing disease classification and prognostic stratification. The combined results strongly advocate that RNA sequencing be introduced into the clinical diagnostic workup of BCP ALL. four decades, most of the recurring chromosomal abnormalities, including aneuploidy, chromosomal rearrangements/gene fusions (e.g., ETV6–RUNX1, BCR–ABL1, and TCF3–PBX1), and rearrangements of KMT2A (previously MLL), were identified by.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a BCP ALL
653 a Gene fusion
653 a Gene mutation
653 a RNA-seq
653 a Subtypes
7001 a Dai, Yu Tingu Ruijin Hospital,Shanghai Jiao Tong University4 aut
7001 a Lilljebjörn, Henriku Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups4 aut0 (Swepub:lu)tmb-hli
7001 a Shen, Shu Hongu Shanghai Jiao Tong University,Shanghai Children’s Medical Center4 aut
7001 a Cui, Bo Wenu Shanghai Jiao Tong University,Ruijin Hospital4 aut
7001 a Bai, Lingu Shanghai Jiao Tong University,Ruijin Hospital4 aut
7001 a Liu, Yuan Fangu Ruijin Hospital,Shanghai Jiao Tong University4 aut
7001 a Qian, Mao Xiangu St Jude Children´s Research Hospital, Memphis4 aut
7001 a Kubota, Yasuou University of Tokyo4 aut
7001 a Kiyoi, Hitoshiu Nagoya University4 aut
7001 a Matsumura, Itaruu Kindai University4 aut
7001 a Miyazaki, Yasushiu Nagasaki University4 aut
7001 a Olsson, Lindau Lund University,Lunds universitet,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups4 aut0 (Swepub:lu)med-ldo
7001 a Tan, Ah Moyu KK Women’s and Children’s Hospital4 aut
7001 a Ariffin, Hanyu University of Malaya4 aut
7001 a Chen, Jingu Shanghai Jiao Tong University,Shanghai Children’s Medical Center4 aut
7001 a Takita, Junkou Kyoto University4 aut
7001 a Yasuda, Takahikou National Hospital Organization, Japan4 aut
7001 a Mano, Hiroyukiu National Cancer Center Research Institute, Japan4 aut
7001 a Johansson, Bertilu Lund University,Lunds universitet,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)kgen-bjo
7001 a Yang, Jun J.u St Jude Children´s Research Hospital, Memphis4 aut
7001 a Yeoh, Allen Eng Juhu National University of Singapore4 aut
7001 a Hayakawa, Fumihikou Nagoya University4 aut
7001 a Chen, Zhuu Shanghai Jiao Tong University,Ruijin Hospital4 aut
7001 a Pui, Ching Honu St Jude Children´s Research Hospital, Memphis4 aut
7001 a Fioretos, Thoasu Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)kgen-tfi
7001 a Chen, Sai Juanu Ruijin Hospital,Shanghai Jiao Tong University4 aut
7001 a Huang, Jin Yanu Shanghai Jiao Tong University,Ruijin Hospital4 aut
7102 a Ruijin Hospitalb Shanghai Jiao Tong University4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 115:50, s. 11711-11720q 115:50<11711-11720x 0027-8424
7730 t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 115:50, s. 11711-11720q 115:50<11711-11720x 1091-6490
8564 u http://dx.doi.org/10.1073/pnas.1814397115y FULLTEXT
8564 u https://www.pnas.org/content/pnas/115/50/E11711.full.pdf
8564 8u https://lup.lub.lu.se/record/26dd769e-7441-41b5-8b35-a9ee3b58942e
8564 8u https://doi.org/10.1073/pnas.1814397115

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