Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss

Lewis, William H (author): Uppsala universitet,Molekylär evolution,Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England;Wageningen Univ, Dept Agrotechnol & Food Sci, Lab Microbiol, Wageningen, Netherlands

Sendra, Kacper M. (author): Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England

Onsbring Gustafson, Henning (author): Uppsala universitet,Molekylär evolution,Wageningen Univ, Dept Agrotechnol & Food Sci, Lab Microbiol, Wageningen, Netherlands

Williams, Tom A. (author): Univ Bristol, Sch Biol Sci, Bristol, Avon, England

Esteban, Genoveva F. (author): Bournemouth Univ, Dept Life & Environm Sci, Poole, Dorset, England

Hirt, Robert P. (author): Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England

Ettema, Thijs J. G. (author): Uppsala universitet,Molekylär evolution,Wageningen Univ, Dept Agrotechnol & Food Sci, Lab Microbiol, Wageningen, Netherlands

Embley, T. Martin (author): Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England

(creator_code:org_t)

2019-10-24
2020
English.
In: Molecular biology and evolution. - : OXFORD UNIV PRESS. - 0737-4038 .- 1537-1719. ; 37:2, s. 524-539

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Abstract Subject headings

Hydrogenosomes are H-2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H-2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H-2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.

By the author/editor: Lewis, William H; Lind, Anders E.; Sendra, Kacper M ...; Onsbring Gustafs ...; Williams, Tom A.; Esteban, Genovev ...; show more...; Hirt, Robert P.; Ettema, Thijs J. ...; Embley, T. Marti ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Evolutionary Bio ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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