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Bridging the gaps i...
Bridging the gaps in systems biology
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- Cvijovic, Marija, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Almquist, Joachim, 1980 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Humboldt-Universität zu Berlin,Humboldt University of Berlin
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- Hagmar, Jonas, 1974 (author)
- Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics (FCC)
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- Hohmann, Stefan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Kaltenbach, H. M. (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Klipp, E. (author)
- Humboldt-Universität zu Berlin,Humboldt University of Berlin
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- Krantz, M. (author)
- Humboldt-Universität zu Berlin,Humboldt University of Berlin
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- Mendes, P. (author)
- University of Manchester
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- Nelander, Sven (author)
- Uppsala universitet,Cancer och vaskulärbiologi
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Pagnani, A. (author)
- Politecnico di Torino,Polytechnic University of Turin
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- Przulj, N. (author)
- Imperial College of Science, Technology and Medicine
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- Raue, A. (author)
- Albert-Ludwigs-Universität Freiburg,University of Freiburg
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- Stelling, J. (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Stoma, S. (author)
- Institut National de Recherche en Informatique et en Automatique (INRIA)
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Tobin, F. (author)
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Wodke, J. A. H. (author)
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- Zecchina, R. (author)
- Politecnico di Torino,Polytechnic University of Turin
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- Jirstrand, Mats, 1968 (author)
- Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics (FCC)
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(creator_code:org_t)
- 2014-04-13
- 2014
- English.
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In: Molecular Genetics and Genomics. - : Springer Science and Business Media LLC. - 1617-4615 .- 1617-4623. ; 289:5, s. 727-734
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Systems biology aims at creating mathematical models, i.e., computational reconstructions of biological systems and processes that will result in a new level of understanding-the elucidation of the basic and presumably conserved "design" and "engineering" principles of biomolecular systems. Thus, systems biology will move biology from a phenomenological to a predictive science. Mathematical modeling of biological networks and processes has already greatly improved our understanding of many cellular processes. However, given the massive amount of qualitative and quantitative data currently produced and number of burning questions in health care and biotechnology needed to be solved is still in its early phases. The field requires novel approaches for abstraction, for modeling bioprocesses that follow different biochemical and biophysical rules, and for combining different modules into larger models that still allow realistic simulation with the computational power available today. We have identified and discussed currently most prominent problems in systems biology: (1) how to bridge different scales of modeling abstraction, (2) how to bridge the gap between topological and mechanistic modeling, and (3) how to bridge the wet and dry laboratory gap. The future success of systems biology largely depends on bridging the recognized gaps.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- Systems biology
- Modeling
- Sensitivity analysis
- Model merging
- Model standards
- Systems biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cvijovic, Marija ...
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Almquist, Joachi ...
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Hagmar, Jonas, 1 ...
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Hohmann, Stefan, ...
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Kaltenbach, H. M ...
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Klipp, E.
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show more...
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Krantz, M.
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Mendes, P.
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Nelander, Sven
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Nielsen, Jens B, ...
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Pagnani, A.
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Przulj, N.
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Raue, A.
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Stelling, J.
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Stoma, S.
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Tobin, F.
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Wodke, J. A. H.
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Zecchina, R.
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Jirstrand, Mats, ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
- Articles in the publication
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Molecular Geneti ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Uppsala University