WFRF:(Ohlsson Per)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03729naa a2200397 4500 | |
| 001 | oai:lup.lub.lu.se:e68663c2-6920-4075-8cf2-5f3e7214a4c8 | |
| 003 | SwePub | |
| 008 | 240422s2024 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/e68663c2-6920-4075-8cf2-5f3e7214a4c82 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-024-59156-72 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Alsved, Juliau AcouSort AB4 aut |
| 245 | 1 0 | a Label-free separation of peripheral blood mononuclear cells from whole blood by gradient acoustic focusing |
| 264 | 1 | c 2024 |
| 300 | a 12 s. | |
| 520 | a Efficient techniques for separating target cells from undiluted blood are necessary for various diagnostic and research applications. This paper presents acoustic focusing in dense media containing iodixanol to purify peripheral blood mononuclear cells (PBMCs) from whole blood in a label-free and flow-through format. If the blood is laminated or mixed with iodixanol solutions while passing through the resonant microchannel, all the components (fluids and cells) rearrange according to their acoustic impedances. Red blood cells (RBCs) have higher effective acoustic impedance than PBMCs. Therefore, they relocate to the pressure node despite the dense medium, while PBMCs stay near the channel walls due to their negative contrast factor relative to their surrounding medium. By modifying the medium and thus tuning the contrast factor of the cells, we enriched PBMCs relative to RBCs by a factor of 3600 to 11,000 and with a separation efficiency of 85%. That level of RBC depletion is higher than most other microfluidic methods and similar to that of density gradient centrifugation. The current acoustophoretic chip runs up to 20 µl/min undiluted whole blood and can be integrated with downstream analysis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng |
| 653 | a Leukocytes, Mononuclear | |
| 653 | a Cell Separation/methods | |
| 653 | a Triiodobenzoic Acids | |
| 653 | a Acoustics | |
| 653 | a Microfluidic Analytical Techniques/methods | |
| 700 | 1 | a Rezayati Charan, Mahdiu Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)ma1140ch |
| 700 | 1 | a Ohlsson, Pelleu Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,AcouSort AB4 aut0 (Swepub:lu)elma-poo |
| 700 | 1 | a Urbansky, Ankeu AcouSort AB4 aut0 (Swepub:lu)med-auy |
| 700 | 1 | a Augustsson, Peru Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)elma-pra |
| 710 | 2 | a AcouSort ABb Avdelningen för Biomedicinsk teknik4 org |
| 773 | 0 | t Scientific Reportsg 14:1q 14:1x 2045-2322 |
| 856 | 4 | u http://dx.doi.org/10.1038/s41598-024-59156-7x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/e68663c2-6920-4075-8cf2-5f3e7214a4c8 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-024-59156-7 |
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