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Sökning: WFRF:(Párraga Alba Atienza) > PVT1 interacts with...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005045naa a2200421 4500
001oai:DiVA.org:uu-499941
003SwePub
008230405s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4999412 URI
0247 a https://doi.org/10.3324/haematol.2023.2829652 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nylund, Patricku Uppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab,Helena Jernberg Wiklund4 aut0 (Swepub:uu)patny852
2451 0a PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
264 1b Ferrata Storti Foundation,c 2024
338 a electronic2 rdacarrier
520 a Multiple myeloma is a heterogeneous hematological disease that originates from the bone marrow and is characterized by the monoclonal expansion of malignant plasma cells. Despite novel therapies, multiple myeloma remains clinically challenging. A common feature among patients with poor prognosis is the increased activity of the epigenetic silencer EZH2, which is the catalytic subunit of the PRC2. Interestingly, the recruitment of PRC2 lacks sequence specificity and, to date, the molecular mechanisms that define which genomic locations are destined for PRC2-mediated silencing remain unknown. The presence of a long non-coding RNA (lncRNA)-binding pocket on EZH2 suggests that lncRNA could potentially mediate PRC2 recruitment to specific genomic regions. Here, we coupled RNA immunoprecipitation sequencing, RNA-sequencing and chromatin immunoprecipitation-sequencing analysis of human multiple myeloma primary cells and cell lines to identify potential lncRNA partners to EZH2. We found that the lncRNA plasmacytoma variant translocation 1 (PVT1) directly interacts with EZH2 and is overexpressed in patients with a poor prognosis. Moreover, genes predicted to be targets of PVT1 exhibited H3K27me3 enrichment and were associated with pro-apoptotic and tumor suppressor functions. In fact, PVT1 inhibition independently promotes the expression of the PRC2 target genes ZBTB7C, RNF144A and CCDC136. Altogether, our work suggests that PVT1 is an interacting partner in PRC2-mediated silencing of tumor suppressor and pro-apoptotic genes in multiple myeloma, making it a highly interesting potential therapeutic target.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Garrido-Zabala, Bertau Uppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab,Helena Jernberg Wiklund4 aut0 (Swepub:uu)berga223
7001 a Atienza Párraga, Albau Uppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab,Helena Jernberg Wiklund4 aut0 (Swepub:uu)albat684
7001 a Vasquez, Louellau Department of Laboratory Medicine, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Lund University, Lund, Sweden.4 aut
7001 a Pyl, Paul Theodoru Department of Clinical Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory Lund University, Lund, Sweden4 aut
7001 a Harinck, George Mickhaelu Uppsala universitet,Cancerprecisionsmedicin,Helena Jernberg Wiklund4 aut0 (Swepub:uu)geoha454
7001 a Ma, Anqiu Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.4 aut
7001 a Jin, Jianu Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.4 aut
7001 a Öberg, Fredriku Uppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab,Helena Jernberg Wiklund4 aut0 (Swepub:uu)fredober
7001 a Kalushkova, Antoniau Uppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab,Helena Jernberg Wiklund4 aut0 (Swepub:uu)antka573
7001 a Jernberg Wiklund, Helenau Uppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab,Helena Jernberg Wiklund4 aut0 (Swepub:uu)helenajw
7102 a Uppsala universitetb Cancerprecisionsmedicin4 org
7730 t Haematologicad : Ferrata Storti Foundationg 109:2, s. 567-577q 109:2<567-577x 0390-6078x 1592-8721
8564 u https://doi.org/10.3324/haematol.2023.282965y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1749057/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-499941
8564 8u https://doi.org/10.3324/haematol.2023.282965

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