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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009533naa a2200649 4500
001oai:DiVA.org:liu-121132
003SwePub
008150908s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:131041575
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1211322 URI
0247 a https://doi.org/10.1038/ng.32452 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1310415752 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Onengut-Gumuscu, Sunau Center for Public Health Genomics, Univ Department of Medicine, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USA4 aut
2451 0a Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
264 c 2015-03-09
264 1b Springer Science and Business Media LLC,c 2015
338 a print2 rdacarrier
520 a Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions, finding major pathways contributing to risk, with some loci shared across immune disorders. To make genetic comparisons across autoimmune disorders as informative as possible, a dense genotyping array, the Immunochip, was developed, from which we identified four new T1D-associated regions (P < 5 × 10(-8)). A comparative analysis with 15 immune diseases showed that T1D is more similar genetically to other autoantibody-positive diseases, significantly most similar to juvenile idiopathic arthritis and significantly least similar to ulcerative colitis, and provided support for three additional new T1D risk loci. Using a Bayesian approach, we defined credible sets for the T1D-associated SNPs. The associated SNPs localized to enhancer sequences active in thymus, T and B cells, and CD34(+) stem cells. Enhancer-promoter interactions can now be analyzed in these cell types to identify which particular genes and regulatory sequences are causal.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Chen, Wei-Minu Center for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA4 aut
7001 a Burren, Oliveru Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Cooper, Nick Ju Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Quinlan, Aaron Ru Center for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA4 aut
7001 a Mychaleckyj, Josyf Cu Center for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA4 aut
7001 a Farber, Emilyu Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA4 aut
7001 a Bonnie, Jessica Ku Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA4 aut
7001 a Szpak, Michalu Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA4 aut
7001 a Schofield, Ellenu Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Achuthan, Premanandu Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Guo, Huiu Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Fortune, Mary Du Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Stevens, Helenu Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Walker, Neil Mu Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Ward, Lucas Du Department of Computer Science, Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA4 aut
7001 a Kundaje, Anshulu Department of Computer Science, Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA / Department of Genetics, Stanford University, Stanford, California, USA / Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA4 aut
7001 a Kellis, Manolisu Department of Computer Science, Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA4 aut
7001 a Daly, Mark Ju Broad Institute of MIT and Harvard, Cambridge, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA4 aut
7001 a Barrett, Jeffrey Cu Wellcome Trust Sanger Institute, Hinxton, UK4 aut
7001 a Cooper, Jason Du Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Deloukas, Panosu Wellcome Trust Sanger Institute, Hinxton, UK4 aut
7001 a Todd, John Au Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK4 aut
7001 a Wallace, Chrisu Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Medical Research Council (MRC) Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK4 aut
7001 a Concannon, Patricku Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA4 aut
7001 a Rich, Stephen Su Center for Public Health Genomics, University of Virginia, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, Charlottesville, Virginia, USA4 aut
7001 a Ludvigsson, Johnnyu Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten4 ctb0 (Swepub:liu)johlu29
7102 a Center for Public Health Genomics, Univ Department of Medicine, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USAb Center for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA4 org
7730 t Nature Geneticsd : Springer Science and Business Media LLCg 47:4, s. 381-386q 47:4<381-386x 1061-4036x 1546-1718
8564 u https://europepmc.org/articles/pmc4380767?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121132
8564 8u https://doi.org/10.1038/ng.3245
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:131041575

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