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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005872naa a2200613 4500
001oai:DiVA.org:du-28533
003SwePub
008181001s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-363419
009oai:prod.swepub.kib.ki.se:139244362
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-285332 URI
0247 a https://doi.org/10.1016/j.rmed.2018.09.0092 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3634192 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1392443622 URI
040 a (SwePub)dud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rydell, Andreasu Karolinska Institutet4 aut
2451 0a Endothelial dysfunction is associated with impaired lung function in two independent community cohorts
264 1b Elsevier BV,c 2018
338 a print2 rdacarrier
520 a BackgroundPrior studies investigating the association between endothelial dysfunction and impaired lung function have been small and inconsistent. The primary aim was to investigate the association between endothelial function and lung function in two community-based cohorts.MethodsWe used a discovery/replication approach to study the association between endothelial function and lung function in the Prospective investigation of Obesity, Energy and Metabolism (POEM, discovery cohort, n = 490, mean age 50.3 ± 0.2 years) and the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, replication cohort, n = 892, mean age 70.2 ± 0.15 years). Spirometry and three different measures of endothelial function were performed including both the invasive forearm technique (endothelium-dependent and endothelium-independent vasodilation [EDV and EIDV, respectively] and noninvasive flow mediated dilation [FMD]).ResultsAn age and sex adjusted association between lower EDV and lower FEV1 was found in POEM and replicated in PIVUS. After merging the two cohorts, 1 standard deviation decrease in EDV was associated with 1.57% lower FEV1 after additional adjustment for smoking status, body mass index, exercise level, and C-reactive protein (95% confidence intervals 0.63–2.51, p = 0.001). The association was slightly lower albeit still statistically significant after excluding participants without cardiovascular disease and chronic respiratory disease and appeared stronger among previous/current smokers vs. non-smokers and in men vs. women (p for interaction = 0.2 and 0.02 respectively).ConclusionsOur findings suggest that even individuals with sub-clinical impairments of lung function in the community have concomitant endothelial dysfunction.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Lung function
653 a Endothelial function
653 a Endothelial dependent vasodilation
653 a Forced expiratory volume
653 a Hälsa och välfärd
653 a Health and Welfare
7001 a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn
7001 a Lisspers, Karin,c Docent,d 1954-u Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)kalis120
7001 a Ställberg, Björn,c Docentu Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)bjsta623
7001 a Nowak, Christophu Karolinska Institutet4 aut
7001 a Carlsson, Axel Cu Karolinska Institutet,Uppsala universitet,Lung- allergi- och sömnforskning,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden4 aut0 (Swepub:uu)axeca883
7001 a Feldreich, Tobiasu Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden4 aut
7001 a Iggman, Davidu Uppsala universitet,Klinisk nutrition och metabolism,Norslund Svardsjo Primary Hlth Care Ctr, Dalarna Cty Council, Falun, Sweden4 aut0 (Swepub:uu)davig338
7001 a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind
7001 a Ärnlöv, Johan,d 1970-u Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden;Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden;Norslund Svardsjo Primary Hlth Care Ctr, Dalarna Cty Council, Falun, Sweden4 aut0 (Swepub:du)jan
7102 a Karolinska Institutetb Lung- allergi- och sömnforskning4 org
7730 t Respiratory Medicined : Elsevier BVg 143, s. 123-128q 143<123-128x 0954-6111x 1532-3064
8564 u http://www.resmedjournal.com/article/S0954611118302919/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-28533
8564 8u https://doi.org/10.1016/j.rmed.2018.09.009
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363419
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139244362

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