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Cerebral glutamine ...
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Samuelsson, CarolinaUppsala universitet,Neurokirurgi
(författare)
Cerebral glutamine and glutamate levels in relation to compromised energy metabolism : a microdialysis study in subarachnoid hemorrhage patients
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-01-17
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SAGE Publications,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-97026
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97026URI
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https://doi.org/10.1038/sj.jcbfm.9600433DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Astrocytic glutamate (Glt) uptake keeps brain interstitial Glt levels low. Within the astrocytes Glt is converted to glutamine (Gln), which is released and reconverted to Glt in neurons. The Glt–Gln cycle is energy demanding and impaired energy metabolism has been suggested to cause low interstitial Gln/Glt ratios. Using microdialysis (MD) measurements from visually noninjured cortex in 33 neurointensive care patients with subarachnoid hemorrhage, we have determined how interstitial Glt and Gln, as a reflection of the Glt–Gln cycle turnover, relate to perturbed energy metabolism. A total of 3703 hourly samples were analyzed. The lactate/pyruvate (L/P) ratios correlated to the Gln/Glt ratios (r=-0.66), but this correlation was not stronger than the correlation between L/P and Glt (r=0.68) or the correlation between lactate and Glt (r=0.65). A novel observation was a linear relationship between interstitial pyruvate and Gln (r=0.52). There were 13 periods (404 h) of 'energy crisis', defined by L/P ratios above 40. All were associated with high interstitial Glt levels. Periods with L/P ratios above 40 and low pyruvate levels were associated with decreased interstitial Gln levels, suggesting ischemia and failing astrocytic Gln synthesis. Periods with L/P ratios above 40 and normal or high pyruvate levels were associated with increased interstitial Gln levels, which may represent an astrocytic hyperglycolytic response to high interstitial Glt levels. The results imply that moderately elevated L/P ratios cannot always be interpreted as failing energy metabolism and that interstitial pyruvate levels may discriminate whether or not there is sufficient astrocytic capacity for Glt–Gln cycling in the brain.
Ämnesord och genrebeteckningar
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brain
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glutamate
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glutamine
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lactate
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microdialysis
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pyruvate
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hillered, LarsUppsala universitet,Neurokirurgi(Swepub:uu)larshill
(författare)
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Zetterling, MariaUppsala universitet,Neurokirurgi(Swepub:uu)mazet677
(författare)
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Enblad, PerUppsala universitet,Neurokirurgi(Swepub:uu)perenbla
(författare)
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Hesselager, GöranUppsala universitet,Neurokirurgi(Swepub:uu)goranhlr
(författare)
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Ryttlefors, MatsUppsala universitet,Neurokirurgi(Swepub:uu)majoh517
(författare)
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Kumlien, EvaUppsala universitet,Neurologi(Swepub:uu)evakumli
(författare)
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Lewén, AndersUppsala universitet,Neurokirurgi(Swepub:uu)andelewe
(författare)
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Marklund, NiklasUppsala universitet,Neurokirurgi(Swepub:uu)niklmark
(författare)
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Nilsson, PelleUppsala universitet,Neurokirurgi(Swepub:uu)pellnils
(författare)
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Salci, KonstantinUppsala universitet,Neurokirurgi(Swepub:uu)konssalc
(författare)
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Ronne-Engström, ElisabethUppsala universitet,Neurokirurgi(Swepub:uu)elisronn
(författare)
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Uppsala universitetNeurokirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Cerebral Blood Flow and Metabolism: SAGE Publications27:7, s. 1309-13170271-678X1559-7016
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Samuelsson, Caro ...
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Hillered, Lars
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Zetterling, Mari ...
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Enblad, Per
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Hesselager, Göra ...
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Ryttlefors, Mats
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Kumlien, Eva
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Lewén, Anders
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Marklund, Niklas
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Nilsson, Pelle
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