WFRF:(Steven K)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02291naa a2200301 4500 | |
| 001 | oai:DiVA.org:uu-89708 | |
| 003 | SwePub | |
| 008 | 020327s2000 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-897082 URI |
| 024 | 7 | a https://doi.org/10.1006/bbrc.2000.38472 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lindholm, Cecilia Ku Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
| 245 | 1 0 | a Shf, a Shb-like Adapter protein, Is Involved in PDGF-a-receptor Regulation of Apoptosis |
| 264 | 1 | b Elsevier BV,c 2000 |
| 338 | a print2 rdacarrier | |
| 500 | a De två första författarna delar förstaförfattarskapet. | |
| 520 | a Recent work has implicated the importance of adapter proteins in signal transduction. To identify homologues of the previously identified adapter protein Shb, database searches were performed. A Shb-like protein was found which we have named Shf. Shf contains an SH2 domain and four putative tyrosine phosphorylation sites and is mainly expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine, and colon. The SH2 domain of Shf bound to the PDGF-alpha-receptor at tyrosine-720, but not to the PDGF-beta-receptor in PAE cells. Pervanadate induced tyrosine phosphorylation of Shf in NIH3T3 fibroblasts overexpressing this protein, whereas PDGF-AA alone had no detectable effect. NIH3T3 cells overexpressing Shf displayed significantly lower rates of apoptosis than control cells in the presence of PDGF-AA. Our findings suggest a role for the novel adapter Shf in PDGF-receptor signaling and regulation of apoptosis. | |
| 700 | 1 | a Frantz, Daniel J4 aut |
| 700 | 1 | a Shoelson, Steven E4 aut |
| 700 | 1 | a Welsh, Michaelu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)michwels |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
| 773 | 0 | t Biochemical and Biophysical Research Communications - BBRCd : Elsevier BVg 278:3, s. 537-543q 278:3<537-543x 0006-291Xx 1090-2104 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89708 |
| 856 | 4 8 | u https://doi.org/10.1006/bbrc.2000.3847 |
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